Show simple item record

dc.contributor.authorHertel, Nicole
dc.contributor.authorRedies, Christoph
dc.contributor.authorMedina Hernández, Loreta Mª
dc.date.accessioned2017-01-18T11:54:44Z
dc.date.issued2012
dc.identifier.issn0021-9967
dc.identifier.urihttp://hdl.handle.net/10459.1/59025
dc.description.abstractThe amygdaloid complex represents a group of telencephalic nuclei and cortical areas that control emotional and social behavior. Amygdalar development is poorly understood. It is generally accepted that the structures of the amygdala originate from the neuroepithelium at both sides of the pallial–subpallial boundary. In the present study, we mapped the expression of 13 members of the cadherin superfamily of cell adhesion molecules, which provide an adhesive code for the development and maintenance of functional structures in the central nervous system (CNS). Five classic cadherins (Cdh4, Cdh6, Cdh7, Cdh8, Cdh11) and eight delta-protocadherins (Pcdh1, Pcdh7, Pcdh8, Pcdh9, Pcdh10, Pcdh11, PCdh17, PCdh19) were studied by in situ hybridization in the postnatal (P5) and adult mouse amygdala. In the different parts of the amygdala, each of these (proto-) cadherins shows a distinct and spatially restricted expression pattern that is highly similar at postnatal and adult stages. The combinatorial expression of (proto-) cadherins allows the distinction of multiple molecular subdivisions within the amygdala that partially coincide with previously described morphological divisions. Beyond these expected results, a number of novel molecular subdivisions and subpopulations of cells were identified; for example, additional molecular subdomains, patches, or cell aggregates with distinct (proto-) cadherin expression in several nuclei/ areas of the amygdala. We also show that several cadherins are molecular markers for particular functional subsystems within the amygdala, such as in the olfactory projections. In summary, (proto-) cadherins provide a code of potentially adhesive cues that can aid the understanding of functional organization in the amygdala. J. Comp. Neurol. 520:3982–4012, 2012.ca_ES
dc.description.sponsorshipGrant sponsor: international exchange between Germany and Spain; Grant number: HD2008-0069 (to C.R. and L.M.); Grant sponsor: Spanish Ministry of Education and Science and FEDER, DGICYT-FEDER; Grant number: BFU2009-07212/BFI (to L.M.).ca_ES
dc.language.isoengca_ES
dc.publisherWileyca_ES
dc.relationMICINN/PN2008-2011/BFU2009-07212/BFI
dc.relation.isformatofReproducció del document publicat a https://doi.org/10.1002/cne.23140ca_ES
dc.relation.ispartofThe Journal of Comparative Neurology, 2012, vol. 520, núm. 17, p. 3982-4012ca_ES
dc.rights(c) Wiley Periodicals, Inc., 2012ca_ES
dc.subjectCell adhesionca_ES
dc.subjectAmygdaloid complexca_ES
dc.subjectProtocadherinca_ES
dc.subjectDevelopmentca_ES
dc.titleCadherin expression delineates the divisions of the postnatal and adult mouse amygdalaca_ES
dc.typearticleca_ES
dc.identifier.idgrec017682
dc.type.versionpublishedVersionca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccessca_ES
dc.identifier.doihttps://doi.org/10.1002/cne.23140
dc.date.embargoEndDate2025-01-01


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record