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dc.contributor.authorAbellán Ródenas, Antonio
dc.contributor.authorDesfilis, Ester
dc.contributor.authorMedina Hernández, Loreta Mª
dc.date.accessioned2017-01-18T11:42:24Z
dc.date.issued2013
dc.identifier.issn0003-276X
dc.identifier.urihttp://hdl.handle.net/10459.1/59024
dc.description.abstractIn tetrapods, the medial amygdala is a forebrain center that integrates olfactory and/or vomeronasal signals with the endocrine and autonomic systems, playing a key role in different social behaviors. The vomeronasal system has undergone important changes during evolution, which may be behind some interspecies differences in chemosensory-mediated social behavior. These evolutionary changes are associated with variations in vomeronasal-recipient brain structures, including the medial amygdala. Herein, we employed an evolutionary developmental biology approach for trying to understand the function and evolution of the medial amygdala. For that purpose, we reviewed published data on fate mapping in mouse, and the expression of orthologous developmental regulatory genes (Nkx2.1, Lhx6, Shh, Tbr1, Lhx9, Lhx5, Otp, and Pax6) in embryos of mouse, chicken, emydid turtles, and a pipid frog. We also analyzed novel data on Lhx9 and Otp in a lacertid lizard. Based on distinct embryonic origin and genetic profile, at least five neuronal subpopulations exist in the medial amygdala of rodents, expressing either Nkx2.1/Lhx6, Shh, Lhx9, Otp/Lhx5, or Pax6. Each neuronal subpopulation appears involved in different functional pathways. For example, Lhx6 cells are specifically activated by sex pheromones and project to preoptic and hypothalamic centers involved in reproduction. Based on data in nonmammals, at least three of these neuronal subtypes might have been present in the medial amygdala of the amniote common ancestor. During mammalian evolution, the downregulation of Nkx2.1 in the alar hypothalamus may have been a driving force for an increment of the Otp/Lhx5 subpopulation.ca_ES
dc.description.sponsorshipGrant sponsor: Spanish Ministry of Science and Innovation; Grant sponsor: FEDER (Fondo Europeo de Desarrollo Regional); Grant no. BFU2009-07212; Grant sponsor: Spanish Ministry of Economy and Competitivity. Grant no. BFU2012-33029.ca_ES
dc.language.isoengca_ES
dc.publisherWileyca_ES
dc.relationMICINN/PN2008-2011/BFU2009-07212
dc.relationMICINN/PN2008-2011/BFU2012-33029
dc.relation.isformatofReproducció del document publicat a https://doi.org/10.1002/ar.22744ca_ES
dc.relation.ispartofThe Anatomical Record, 2013, vol. 296, núm. 9, p. 1317-1332ca_ES
dc.rights(c) Wiley Periodicals, Inc., 2013ca_ES
dc.subjectVomeronasal systemca_ES
dc.subjectPheromonesca_ES
dc.subjectMedial amygdalaca_ES
dc.subjectDevelopmental regulatory genesca_ES
dc.titleThe olfactory amygdala in amniotes: an evo-devo approachca_ES
dc.typearticleca_ES
dc.identifier.idgrec019769
dc.type.versionpublishedVersionca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccessca_ES
dc.identifier.doihttps://doi.org/10.1002/ar.22744
dc.date.embargoEndDate2025-01-01


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