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dc.contributor.authorBupesh, Munisamy
dc.contributor.authorVicario Andrade, Alba
dc.contributor.authorAbellán Ródenas, Antonio
dc.contributor.authorDesfilis, Ester
dc.contributor.authorMedina Hernández, Loreta Mª
dc.date.accessioned2017-01-18T11:28:59Z
dc.date.issued2013
dc.identifier.issn1863-2653
dc.identifier.urihttp://hdl.handle.net/10459.1/59023
dc.description.abstractEmotional and motivational dysfunctions observed in Parkinson’s disease, schizophrenia, and drug addiction are associated to an alteration of the mesocortical and mesolimbic dopaminergic pathways, which include axons projecting to the prefrontal cortex, the ventral striatum, and the amygdala. Subpopulations of catecholaminergic neurons have been described in the cortex and striatum of several mammals, but the presence of such cells in the adult amygdala is unclear in murine rodents, and in other rodents appears to show variations depending on the species. Moreover, the embryonic origin of telencephalic tyrosine hydroxylase (TH) cells is unknown, which is essential for trying to understand aspects of their evolution, distribution and function. Herein we investigated the expression of TH mRNA and protein in cells of the striatum and amygdala of developing and adult mice, and analyzed the embryonic origin of such cells using in vitro migration assays. Our results showed the presence of TH mRNA and protein expressing cells in the striatum (including nucleus accumbens), central and medial extended amygdala during development, which are persistent in adulthood although they are less numerous, generally show weak mRNA expression, and some appear to lack the protein. Fate mapping analysis showed that these cells include at least two subpopulations with different embryonic origin in either the commissural preoptic area of the subpallium or the supraopto-paraventricular domain of the alar hypothalamus. These data are important for future studies trying to understand the role of catecholamines in modulation of emotion, motivation, and reward.ca_ES
dc.description.sponsorshipSupported by a grant to L.M. from the Spanish Ministry of Science and Innovation, and Fondo Europeo de Desarrollo Regional (DGICYT-FEDER: grant reference BFU2009-07212/BFI), Spanish Ministry of Economy and Competitivity (grant reference BFU2012-33029). M.B. and A.V. had predoctoral fellowships from the Spanish Ministry of Education and Science. We thank Dr. Faustino Marı´n (Univ. of Murcia, Spain), who kindly sent us the cDNA for TH.ca_ES
dc.language.isoengca_ES
dc.publisherSpringer Berlinca_ES
dc.relationMICINN/PN2008-2011/BFU2009-07212/BFI
dc.relationMICINN/PN2008-2011/BFU2012-33029
dc.relation.isformatofReproducció del document publicat a https://doi.org/10.1007/s00429-013-0533-7ca_ES
dc.relation.ispartofBrain Structure and Function, 2014, vol. 219, núm. 3, p. 751-776ca_ES
dc.rights(c) Springer-Verlag Berlin Heidelberg, 2013ca_ES
dc.subjectRewardca_ES
dc.subjectEmotionca_ES
dc.subjectTyrosine hydroxylaseca_ES
dc.subjectDopamineca_ES
dc.titleDynamic expression of tyrosine hydroxylase mRNA and protein in neurons of the striatum and amygdala of mice, and experimental evidence of their multiple embryonic originca_ES
dc.typearticleca_ES
dc.identifier.idgrec019767
dc.type.versionpublishedVersionca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccessca_ES
dc.identifier.doihttps://doi.org/10.1007/s00429-013-0533-7
dc.date.embargoEndDate2025-01-01


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