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dc.contributor.authorSabalza Gallués, Maite
dc.contributor.authorVamvaka, Evangelia
dc.contributor.authorChristou, Paul
dc.contributor.authorCapell Capell, Teresa
dc.date.accessioned2017-01-14T12:28:32Z
dc.date.issued2013
dc.identifier.issn1381-6128
dc.identifier.urihttp://hdl.handle.net/10459.1/58965
dc.description.abstractThe production of recombinant proteins in seeds is achieved by driving transgene expression using promoters and protein targeting sequences derived from genes encoding abundant seed storage proteins. This approach is advantageous because high yields, stability and containment are conferred by the accumulation of recombinant proteins in specialized storage compartments such as protein bodies and protein storage vacuoles. Seeds are particularly suitable for the production of pharmaceutical proteins in developing country settings because they reduce the costs of production and distribution by avoiding the need for fermenter-based production capacity and a cold chain for storage and distribution, thus increasing access to critical medicines for the poor in rural areas. Seeds are also ideal for the production of oral vaccine antigens, because encapsulation within the seed provides protection that prolongs exposure to the gastric immune system and thus increases the potency of the immune response. In this review we discuss the current state of the art in seed-based molecular pharming and the future potential of production platforms based on seeds.ca_ES
dc.description.sponsorshipResearch at the Universitat de Lleida is supported by MICINN, Spain (BFU2007-61413; BIO2011-23324; BIO02011-22525; PIM2010PKB-00746); European Union Framework 7 Program- SmartCell Integrated Project 222716; European Union Framework 7 European Research Council IDEAS Advanced Grant (to PC) Program-BIOFORCE; COST Action FA0804: Molecular farming: plants as a production platform for high value proteins; Centre CONSOLIDER on Agrigenomics funded by MICINN, Spain.ca_ES
dc.language.isoengca_ES
dc.publisherBentham Science Publishersca_ES
dc.relationMIECI/PN2004-2007/BFU2007-61413ca_ES
dc.relationMICINN/PN2008-2011/BIO2011-23324ca_ES
dc.relationMICINN/PN2008-2011/BIO2011-22525ca_ES
dc.relationMICINN/PN2008-2011/PIM2010PKB-00746ca_ES
dc.relation.isformatofReproducció del document publicat a https://doi.org/10.2174/1381612811319310009ca_ES
dc.relation.ispartofCurrent Pharmaceutical Design, 2013, vol. 19, p. 5543-5552ca_ES
dc.rights(c) Bentham Science Publishers, 2013ca_ES
dc.subjectPlant-made pharmaceuticalsca_ES
dc.subjectRecombinant proteinsca_ES
dc.subjectRecombinant antibodiesca_ES
dc.titleSeeds as a production system for molecular pharming applications: status and prospectsca_ES
dc.typearticleca_ES
dc.identifier.idgrec020964
dc.type.versionpublishedVersionca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccessca_ES
dc.identifier.doihttps://doi.org/10.2174/1381612811319310009
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/222716ca_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/232933
dc.date.embargoEndDate2025-01-01


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