Universitat de Lleida
    • English
    • català
    • español
  • English 
    • English
    • català
    • español
  • Login
Repositori Obert UdL
View Item 
  •   Home
  • Recerca
  • Pedagogia i Psicologia
  • Articles publicats (Pedagogia i Psicologia)
  • View Item
  •   Home
  • Recerca
  • Pedagogia i Psicologia
  • Articles publicats (Pedagogia i Psicologia)
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Cocaine-induced behavioral sensitization decreases the expression of endocannabinoid signaling-related proteins in the mouse hippocampus

Thumbnail
View/Open
024941.pdf (1.892Mb)
Sol·licita una còpia
Issue date
2016-03-01
Author
Blanco Calvo, Eduardo
Galeano, Pablo
Palomino, Ana
Pavón, Francisco Javier
Rivera, Patricia
Serrano, Antonia
Alen, Francisco
Rubio, Leticia
Vargas, Antonio
Castilla Ortega, Estela
Decara, Juan
Bilbao, Ainhoa
Rodríguez de Fonseca, Fernando
Suárez, Juan
Suggested citation
Blanco Calvo, Eduardo; Galeano, Pablo; Palomino, Ana; Pavón, Francisco Javier; Rivera, Patricia; Serrano, Antonia; ... Suárez, Juan. (2016) . Cocaine-induced behavioral sensitization decreases the expression of endocannabinoid signaling-related proteins in the mouse hippocampus. European Neuropsychopharmacology, 2016, vol. 26, num. 3, p. 477-492. https://doi.org/10.1016/j.euroneuro.2015.12.040.
Impact


Web of Science logo    citations in Web of Science

Scopus logo    citations in Scopus

Google Scholar logo  Google Scholar
Share
Export to Mendeley
Metadata
Show full item record
Abstract
In the reward mesocorticolimbic circuits, the glutamatergic and endocannabinoid systems are implicated in neurobiological mechanisms underlying cocaine addiction. However, the involvement of both systems in the hippocampus, a critical region to process relational information relevant for encoding drug-associated memories, in cocaine-related behaviors remains unknown. In the present work, we studied whether the hippocampal gene/protein expression of relevant glutamate signaling components, including glutamate-synthesizing enzymes and metabotropic and ionotropic receptors, and the hippocampal gene/protein expression of cannabinoid type 1 (CB1) receptor and endocannabinoid metabolic enzymes were altered following acute and/or repeated cocaine administration resulting in conditioned locomotion and locomotor sensitization. Results showed that acute cocaine administration induced an overall down-regulation of glutamate-related gene expression and, specifically, a low phosphorylation level of GluA1. In contrast, locomotor sensitization to cocaine produced an up-regulation of several glutamate receptor-related genes and, specifically, an increased protein expression of the GluN1 receptor subunit. Regarding the endocannabinoid system, acute and repeated cocaine administration were associated with an increased gene/protein expression of CB1 receptors and a decreased gene/protein expression of the endocannabinoid-synthesis enzymes N-acyl phosphatidylethanolamine D (NAPE-PLD) and diacylglycerol lipase alpha (DAGLα). These changes resulted in an overall decrease in endocannabinoid synthesis/degradation ratios, especially NAPE-PLD/fatty acid amide hydrolase and DAGLα/monoacylglycerol lipase, suggesting a reduced endocannabinoid production associated with a compensatory up-regulation of CB1 receptor. Overall, these findings suggest that repeated cocaine administration resulting in locomotor sensitization induces a down-regulation of the endocannabinoid signaling that could contribute to the specifically increased GluN1 expression observed in the hippocampus of cocaine-sensitized mice.
URI
http://hdl.handle.net/10459.1/58810
DOI
https://doi.org/10.1016/j.euroneuro.2015.12.040
Is part of
European Neuropsychopharmacology, 2016, vol. 26, num. 3, p. 477-492
European research projects
Collections
  • Articles publicats (Pedagogia i Psicologia) [495]

Contact Us | Send Feedback | Legal Notice
© 2022 BiD. Universitat de Lleida
Metadata subjected to 
 

 

Browse

All of the repositoryCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

Statistics

View Usage Statistics

D'interès

Política institucional d'accés obertDiposita les teves publicacionsDiposita dades de recercaSuport a la recerca

Contact Us | Send Feedback | Legal Notice
© 2022 BiD. Universitat de Lleida
Metadata subjected to