Epigenetic profiling to classify cancer of unknown primary: a multicentre, retrospective analysis
Issue date
2016Author
Moran, Sebastian
Martínez Cardús, Anna
Sayols, Sergi
Musulén, Eva
Balañá, Carme
Estival Gonzalez, Anna
Moutinho, Cátia
Heyn, Holger
Diaz Lagares, Angel
Castro de Moura, Manuel
Stella, Giulia M.
Comoglio, Paolo M.
Ruiz Miró, Maria
Pazo Cid, Roberto
Antón, Antonio
Lopez Lopez, Rafael
Soler, Gemma
Longo, Federico
Guerra, Isabel
Fernandez, Sara
Assenov, Yassen
Plass, Christoph
Morales, Rafael
Carles, Joan
Bowtell, David
Mileshkin, Linda
Sia, Daniela
Tothill, Richard
Tabernero, Josep
Llovet, Josep M.
Esteller, Manel
Suggested citation
Moran, Sebastian;
Martínez Cardús, Anna;
Sayols, Sergi;
Musulén, Eva;
Balañá, Carme;
Estival Gonzalez, Anna;
...
Matias-Guiu, Xavier.
(2016)
.
Epigenetic profiling to classify cancer of unknown primary: a multicentre, retrospective analysis.
The Lancet Oncology, 2016, vol. 17, núm. 10, p. 1286-1395.
https://doi.org/10.1016/S1470-2045(16)30297-2.
Metadata
Show full item recordAbstract
Cancer of unknown primary ranks in the top ten cancer presentations and has an extremely poor prognosis. Identification of the primary tumour and development of a tailored site-specific therapy could improve the survival of these patients. We examined the feasability of using DNA methylation profiles to determine the occult original cancer in cases of cancer of unknown primary.
Is part of
The Lancet Oncology, 2016, vol. 17, núm. 10, p. 1286-1395European research projects
Collections
Related items
Showing items related by title, author, creator and subject.
-
Molecular profiling of circulating tumor cells links plasticity to the metastatic process in endometrial cancer
Alonso-Alconada, Lorena; Muinelo-Romay, Laura; Madissoo, Kadri; Díaz-López, Antonio; Krakstad, Camilla; Trovik, Jone; Wik, Elisabeth; Hapangama, Dharani; Coenegrachts, Lieve; Cano, Amparo; Gil-Moreno, Antonio; Chiva, Luís; Cueva, Juan; Vieito, María; Ortega Izquierdo, Maria Eugenia; Mariscal, Javier; Colás, Eva; Castellví, Josep; Cusido, Maite; Dolcet Roca, Xavier; Nijman, Hans W.; Bosse, Tjalling; Green, John A.; Romano, Andrea; Reventós, Jaume; López-López, Rafael; Salvesen, Helga B.; Amant, Frederic; Matias-Guiu, Xavier; Moreno-Bueno, Gema; Abal, Miguel (Biomed Central, 2014)Background: About 20% of patients diagnosed with endometrial cancer (EC) are considered high-risk with unfavorable prognosis. In the framework of the European Network for Individualized Treatment in EC (ENITEC), we ... -
Genomic profiling of primary and recurrent adult granulosa cell tumors of the ovary
Gatius Calderó, Sònia; Cruz Paula, Arnaud Da; Silva, Edaise M. da; Segura, Sheila E.; Pareja, Fresia; Bi, Rui; Selenica, Pier; Kim, Sarah H.; Ferrando, Lorenzo; Vahdatinia, Mahsa; Soslow, Robert A.; Vidal, August; Przybycin, Christopher G.; Abu-Rustum, Nadeem R.; Matias-Guiu, Xavier; Rubin, Brian P.; Reis-Filho, Jorge S.; DeLair, Deborah F.; Weigelt, Britta (2020)Adult-type granulosa cell tumor (aGCT) is a rare malignant ovarian sex cord-stromal tumor, harboring recurrent FOXL2 c.C402G/p.C134W hotspot mutations in 97% of cases. These tumors are considered to have a favorable ... -
High-carotenoid maize: development of plant biotechnology prototypes for human and animal health and nutrition
Zhu, Changfu; Farré Martinez, Gemma; Zanga, Daniela; Lloveras Vilamanyà, Jaume; Michelena Bárcena, Antonio; Ferrio Díaz, Juan Pedro; Voltas Velasco, Jordi; Slafer, Gustavo A.; Savin, Roxana; Albajes Garcia, Ramon; Eizaguirre Altuna, Matilde; López Alonso, Carmen; Cantero-Martínez, Carlos; Díaz Gómez, Joana; Nogareda, Carmina; Moreno Martínez, José Antonio; Angulo Asensio, Eduardo; Estany Illa, Joan; Pena i Subirà, Ramona Natacha; Tor i Naudí, Marc; Portero Otín, Manuel; Eritja Sánchez, Núria; Arjó Pont, Gemma; Serrano Casasola, José Carlos Enrique; Matias-Guiu, Xavier; Twyman, Richard M.; Sandmann, Gerhard; Capell Capell, Teresa; Christou, Paul (Springer Verlag, 2017-06-01)Carolight® is a transgenic maize variety that accumulates extraordinary levels of carotenoids, including those with vitamin A activity. The development of Carolight® maize involved the technical implementation of a novel ...