Universitat de Lleida
    • English
    • català
    • español
  • català 
    • English
    • català
    • español
  • Inicia la sessió
Repositori Obert UdL
Visualitza l'element 
  •   Inici
  • Recerca
  • Medicina Experimental
  • Articles publicats (Medicina Experimental)
  • Visualitza l'element
  •   Inici
  • Recerca
  • Medicina Experimental
  • Articles publicats (Medicina Experimental)
  • Visualitza l'element
JavaScript is disabled for your browser. Some features of this site may not work without it.

Depletion of oxidative and endoplasmic reticulum stress regulators in Pick disease

Thumbnail
Visualitza/Obre
015600.pdf (1.176Mb)
Sol·licita una còpia
Data de publicació
2010
Autor/a
Ilieva, Ekaterina V.
Naudí i Farré, Alba
Kichev, Anton Vladimirov
Ferrer, Isidre
Pamplona Gras, Reinald
Portero Otín, Manuel
Citació recomanada
Ilieva, Ekaterina V.; Naudí i Farré, Alba; Kichev, Anton Vladimirov; Ferrer, Isidre; Pamplona Gras, Reinald; Portero Otín, Manuel; . (2010) . Depletion of oxidative and endoplasmic reticulum stress regulators in Pick disease. Free Radical Biology and Medicine, 2010, vol. 48, núm. 10, p. 1302-1310. https://doi.org/10.1016/j.freeradbiomed.2010.02.006.
Impacte


Logo de Web of Science    citacions a Web of Science

Logo d'Scopus    citacions a Scopus

Logo de Google Acadèmic  Google Acadèmic
Compartir
Exportar a Mendeley
Metadades
Mostra el registre d'unitat complet
Resum
Both oxidative and endoplasmic reticulum (ER) stress is associated with multiple neurodegenerative, age-related diseases. The rare disorder Pick disease (PiD) shares some pathological hallmarks of other neurodegenerative diseases that may be related to oxidative stress. Importantly, activation of an ER stress response, which is also involved in aging, has not yet been investigated in PiD. In this study, we assessed the implication of ER stress associated with oxidative stress in PiD as a potential mechanism involved in its pathogenesis. Samples from morphologically affected frontal cortex and apparently pathologically preserved occipital cortex showed region-dependent increases in different protein oxidative damage pathways. The oxidative modifications targeted antioxidant enzymes, proteases, heat shock proteins, and synaptic proteins. These effects were associated with compromised proteasomal function and ER stress in frontal cortex samples. In addition, we observed a depletion in ER chaperones (glucose-regulated proteins Grp78/BiP and glucose-regulated protein 94) and differences in tissue content and distribution of nuclear factor-erythroid 2 p45-related respiratory 2, required for cell survival during the unfolded protein response. These results demonstrate increased region-specific protein oxidative damage in PiD, with proteasomal alteration and dysfunctional ER stress response. We suggest this was caused by complete and specific depletion of Grp78/BiP, contributing to the pathophysiology of this neurodegenerative disease.
URI
http://hdl.handle.net/10459.1/58674
DOI
https://doi.org/10.1016/j.freeradbiomed.2010.02.006
És part de
Free Radical Biology and Medicine, 2010, vol. 48, núm. 10, p. 1302-1310
Projectes de recerca europeus
Col·leccions
  • Articles publicats (IRBLleida) [1054]
  • Articles publicats (Medicina Experimental) [323]
  • Publicacions de projectes de recerca del Plan Nacional [2627]
  • Articles publicats (Grup de Recerca en Fisiopatologia Metabòlica) [58]
  • Articles publicats (Ciències Mèdiques Bàsiques) [548]

Contacteu amb nosaltres | Envia comentaris | Avís legal
© 2022 BiD. Universitat de Lleida
Metadades subjectes a 
 

 

Explora

Tot el repositoriComunitats i col·leccionsPer data d'edicióAutorsTítolsMatèriesAquesta col·leccióPer data d'edicióAutorsTítolsMatèries

Estadístiques

Veure estadístiques d'ús

D'interès

Política institucional d'accés obertDiposita les teves publicacionsDiposita dades de recercaSuport a la recerca

Contacteu amb nosaltres | Envia comentaris | Avís legal
© 2022 BiD. Universitat de Lleida
Metadades subjectes a