Biomarkers of aging in Drosophila

Visualitza/ Obre
Data de publicació
2010Autor/a
Jacobson, Jake
Lambert, Adrian J.
Magwere, Tapiwanashe
Miwa, Satomi
Driege, Yasmine
Brand, Martin D.
Partridge, Linda
Citació recomanada
Jacobson, Jake;
Lambert, Adrian J.;
Portero Otín, Manuel;
Pamplona Gras, Reinald;
Magwere, Tapiwanashe;
Miwa, Satomi;
...
Partridge, Linda.
(2010)
.
Biomarkers of aging in Drosophila.
Aging Cell, 2010, vol. 9, núm. 4, p. 466-477.
https://doi.org/10.1111/j.1474-9726.2010.00573.x.
Metadades
Mostra el registre d'unitat completResum
Low environmental temperature and dietary restriction (DR) extend lifespan in diverse organisms. In the fruit fly Drosophila, switching flies between temperatures alters the rate at which mortality subsequently increases with age but does not reverse mortality rate. In contrast, DR acts acutely to lower mortality risk; flies switched between control feeding and DR show a rapid reversal of mortality rate. Dietary restriction thus does not slow accumulation of aging-related damage. Molecular species that track the effects of temperatures on mortality but are unaltered with switches in diet are therefore potential biomarkers of aging-related damage. However, molecular species that switch upon instigation or withdrawal of DR are thus potential biomarkers of mechanisms underlying risk of mortality, but not of aging-related damage. Using this approach, we assessed several commonly used biomarkers of aging-related damage. Accumulation of fluorescent advanced glycation end products (AGEs) correlated strongly with mortality rate of flies at different temperatures but was independent of diet. Hence, fluorescent AGEs are biomarkers of aging-related damage in flies. In contrast, five oxidized and glycated protein adducts accumulated with age, but were reversible with both temperature and diet, and are therefore not markers either of acute risk of dying or of aging-related damage. Our approach provides a powerful method for identification of biomarkers of aging.
És part de
Aging Cell, 2010, vol. 9, núm. 4, p. 466-477Projectes de recerca europeus
Els fitxers de llicència següents estan associats amb aquest element: