Interpreting ion fluxes to channel arrays in monolayers
Fecha de publicación
2007Autor/a
Monné Esquerda, Josep
Díez, Yolanda
Nelson, Andrew
Cita recomendada
Monné Esquerda, Josep;
Díez, Yolanda;
Puy Llorens, Jaume;
Galceran i Nogués, Josep;
Nelson, Andrew;
.
(2007)
.
Interpreting ion fluxes to channel arrays in monolayers.
Langmuir, 2007, vol. 23, núm. 21, p. 10581-10588.
https://doi.org/10.1021/la701447g.
Metadatos
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The exponentially decaying permeability model interprets the chronoamperometric currents arising from Tl+ reduction
at a Hg electrode covered with a phospholipid monolayer (DOPC) containing gramicidin monomer by combining three
processes: (i) the diffusion of an ion to a membrane surface with an array of channels, (ii) the conformational dynamics
of the individual channels, and (iii) the passage of the ion through the channels. The introduction of a variable
permeability allows us to uncouple the diffusion from the heterogeneous processes, given that the concentration of
a species at the active surface can be obtained by semi-integration of the currents. Consideration of a reverse step
for the dehydration process at the mouth of the channel allows the analysis of potential steps away from diffusionlimited
conditions where a Nernstian-like behavior of the relevant parameter is observed. The model has been successfully
applied to data with all trans retinol or benzo-R-pyrene as additive to the phospholipid monolayer and to monolayers
without any additive at all.