Interpreting ion fluxes to channel arrays in monolayers

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Fecha de publicación
2007
Autor/a
Monné Esquerda, Josep
Díez, Yolanda
Puy Llorens, Jaume
Galceran i Nogués, Josep
Nelson, Andrew
Cita recomendada
Monné Esquerda, Josep; Díez, Yolanda; Puy Llorens, Jaume; Galceran i Nogués, Josep; Nelson, Andrew; . (2007) . Interpreting ion fluxes to channel arrays in monolayers. Langmuir, 2007, vol. 23, núm. 21, p. 10581-10588. https://doi.org/10.1021/la701447g.
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Resumen
The exponentially decaying permeability model interprets the chronoamperometric currents arising from Tl+ reduction at a Hg electrode covered with a phospholipid monolayer (DOPC) containing gramicidin monomer by combining three processes: (i) the diffusion of an ion to a membrane surface with an array
of channels, (ii) the conformational dynamics of the individual channels, and (iii) the passage of the ion through the channels. The introduction of a variable permeability allows us to uncouple the diffusion from the heterogeneous processes, given that the concentration of a species at the active surface can be obtained by semi-integration of the currents. Consideration of a reverse step for the dehydration process at the mouth of the channel allows the analysis of potential steps away from diffusionlimited conditions where a Nernstian-like behavior of the relevant parameter is observed. The model has been successfully applied to data with all trans retinol or benzo-R-pyrene as additive to the phospholipid monolayer and to monolayers without any additive at all.
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http://hdl.handle.net/10459.1/58630
DOI
https://doi.org/10.1021/la701447g
Es parte de
Langmuir, 2007, vol. 23, núm. 21, p. 10581-10588
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