Interpreting ion fluxes to channel arrays in monolayers
Data de publicació2007
Monné Esquerda, Josep
MetadadesMostra el registre d'unitat complet
The exponentially decaying permeability model interprets the chronoamperometric currents arising from Tl+ reduction at a Hg electrode covered with a phospholipid monolayer (DOPC) containing gramicidin monomer by combining three processes: (i) the diffusion of an ion to a membrane surface with an array
of channels, (ii) the conformational dynamics of the individual channels, and (iii) the passage of the ion through the channels. The introduction of a variable permeability allows us to uncouple the diffusion from the heterogeneous processes, given that the concentration of a species at the active surface can be obtained by semi-integration of the currents. Consideration of a reverse step for the dehydration process at the mouth of the channel allows the analysis of potential steps away from diffusionlimited conditions where a Nernstian-like behavior of the relevant parameter is observed. The model has been successfully applied to data with all trans retinol or benzo-R-pyrene as additive to the phospholipid monolayer and to monolayers without any additive at all.
És part deLangmuir, 2007, vol. 23, núm. 21, p. 10581-10588
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