This study explores the relationships between an index of empathy and the Big-Five personality model in a sample of 832 Spanish adolescents. As expected, results show that empathy correlates strongly with Friendliness. Positive correlations with Conscientiousness, Energy, and Openness traits have also been observed, but regression analyses show that relationships of empathy with those three factors were of negligible importance. Contrary to expectations, empathy did not correlate with Emotional stability. This pattern of results was replicated across boys and girls.