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Oxidative stress underlying axonal degeneration in adrenoleukodystrophy: a paradigm for multifactorial neurodegenerative diseases?

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Data de publicació
2012
Autor/a
Galea, Elena
Launay, Nathalie
Portero Otín, Manuel
Ruiz, Montserrat
Pamplona Gras, Reinald
Aubourg, Patrick
Ferrer, Isidre
Pujol, Aurora
Citació recomanada
Galea, Elena; Launay, Nathalie; Portero Otín, Manuel; Ruiz, Montserrat; Pamplona Gras, Reinald; Aubourg, Patrick; ... Pujol, Aurora. (2012) . Oxidative stress underlying axonal degeneration in adrenoleukodystrophy: a paradigm for multifactorial neurodegenerative diseases?. Biochimica et Biophysica Acta, 2012, vol. 1822, núm. 9, p. 1475-1488. https://doi.org/10.1016/j.bbadis.2012.02.005.
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Resum
X-linked adrenoleukodystrophy (X-ALD) is an inherited neurodegenerative disorder expressed as four disease variants characterized by adrenal insufficiency and graded damage in the nervous system. X-ALD is caused by a loss of function of the peroxisomal ABCD1 fatty-acid transporter, resulting in the accumulation of very long chain fatty acids (VLCFA) in the organs and plasma, which have potentially toxic effects in CNS and adrenal glands. We have recently shown that treatment with a combination of antioxidants containing α-tocopherol, N-acetyl-cysteine and α-lipoic acid reversed oxidative damage and energetic failure, together with the axonal degeneration and locomotor impairment displayed by Abcd1 null mice, the animal model of X-ALD. This is the first direct demonstration that oxidative stress, which is a hallmark not only of X-ALD, but also of other neurodegenerative processes, such as Alzheimer's disease (AD), Parkinson's disease (PD) and Huntington's disease (HD), contributes to axonal damage. The purpose of this review is, first, to discuss the molecular and cellular underpinnings of VLCFA-induced oxidative stress, and how it interacts with energy metabolism and/or inflammation to generate a complex syndrome wherein multiple factors are contributing. Particular attention will be paid to the dysregulation of redox homeostasis by the interplay between peroxisomes and mitochondria. Second, we will extend this analysis to the aforementioned neurodegenerative diseases with the aim of defining differences as well as the existence of a core pathogenic mechanism that would justify the exchange of therapeutic opportunities among these pathologies. This article is part of a Special Issue entitled: Metabolic functions and biogenesis of peroxisomes in health and disease.
URI
http://hdl.handle.net/10459.1/58585
DOI
https://doi.org/10.1016/j.bbadis.2012.02.005
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Biochimica et Biophysica Acta, 2012, vol. 1822, núm. 9, p. 1475-1488
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  • Publicacions de projectes de recerca del Plan Nacional [2661]
  • Articles publicats (Grup de Recerca en Fisiopatologia Metabòlica) [58]

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