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Engineering complex metabolic pathways in plants

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Issue date
2014
Author
Farré Martinez, Gemma
Capell Capell, Teresa
Zhu, Changfu
Christou, Paul
Blancquaert, Dieter
Van Der Straeten, Dominique
Suggested citation
Farré Martinez, Gemma; Capell Capell, Teresa; Zhu, Changfu; Christou, Paul; Blancquaert, Dieter; Van Der Straeten, Dominique; . (2014) . Engineering complex metabolic pathways in plants. Annual Review of Plant Biology, 2014, vol. 65, p. 187-223. https://doi.org/10.1146/annurev-arplant-050213-035825.
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Abstract
Metabolic engineering can be used to modulate endogenous metabolic pathways in plants or introduce new metabolic capabilities in order to increase the production of a desirable compound or reduce the accumulation of an undesirable one. In practice, there are several major challenges that need to be overcome, such as gaining enough knowledge about the endogenous pathways to understand the best intervention points, identifying and sourcing the most suitable metabolic genes, expressing those genes in such a way as to produce a functional enzyme in a heterologous background, and, finally, achieving the accumulation of target compounds without harming the host plant. This article discusses the strategies that have been developed to engineer complex metabolic pathways in plants, focusing on recent technological developments that allow the most significant bottlenecks to be overcome.
URI
http://hdl.handle.net/10459.1/58515
DOI
https://doi.org/10.1146/annurev-arplant-050213-035825
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Annual Review of Plant Biology, 2014, vol. 65, p. 187-223
European research projects
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  • Articles publicats (Producció Vegetal i Ciència Forestal) [851]
  • Publicacions de projectes de recerca del Plan Nacional [2948]
  • Publicacions de projectes finançats per la Unió Europea [758]

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