Engineering complex metabolic pathways in plants
Issue date
2014Author
Blancquaert, Dieter
Van Der Straeten, Dominique
Suggested citation
Farré Martinez, Gemma;
Capell Capell, Teresa;
Zhu, Changfu;
Christou, Paul;
Blancquaert, Dieter;
Van Der Straeten, Dominique;
.
(2014)
.
Engineering complex metabolic pathways in plants.
Annual Review of Plant Biology, 2014, vol. 65, p. 187-223.
https://doi.org/10.1146/annurev-arplant-050213-035825.
Metadata
Show full item recordAbstract
Metabolic engineering can be used to modulate endogenous metabolic pathways
in plants or introduce new metabolic capabilities in order to increase
the production of a desirable compound or reduce the accumulation of an
undesirable one. In practice, there are several major challenges that need
to be overcome, such as gaining enough knowledge about the endogenous
pathways to understand the best intervention points, identifying and sourcing
the most suitable metabolic genes, expressing those genes in such a way as
to produce a functional enzyme in a heterologous background, and, finally,
achieving the accumulation of target compounds without harming the host
plant. This article discusses the strategies that have been developed to engineer
complex metabolic pathways in plants, focusing on recent technological
developments that allow the most significant bottlenecks to be overcome.
Is part of
Annual Review of Plant Biology, 2014, vol. 65, p. 187-223European research projects
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