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Progesterone supplementation during mid-gestation increases the risk of abortion in Neospora-infected dairy cows with high antibody titres

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Issue date
2007
Author
Bech Sàbat, Gregori
López Gatius, Fernando
Santolaria Blasco, Pilar
García Ispierto, Irina
Pabón, M.
Nogareda, Carmina
Yániz Pérez de Albéniz, Jesús
Almería, S.
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Bech Sàbat, Gregori; López Gatius, Fernando; Santolaria Blasco, Pilar; García Ispierto, Irina; Pabón, M.; Nogareda, Carmina; ... Almería, S.. (2007) . Progesterone supplementation during mid-gestation increases the risk of abortion in Neospora-infected dairy cows with high antibody titres. Veterinary Parasitology, 2007, vol. 145, núm. 1-2, p. 164-167. https://doi.org/10.1016/j.vetpar.2006.11.018.
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Abstract
Progesterone has been reported to reduce Th1 responses during pregnancy. Thus, given that an excessive Th1 response could lead to abortion in Neospora-infected dairy cows, we hypothesized a reduction in abortion risk following progesterone supplementation during the mid-gestation period in these animals. Seropositive animals were assigned on day 120 of gestation to a Control (n = 33) or Treatment (n = 34) group. Treatment consisted of progesterone supplementation by fitting a progesterone releasing intravaginal device containing 1.55 g of progesterone for 28 days. Mean Neospora caninum antibody titres tested by ELISA on days 40, 90 and 120 of gestation were used to classify the cows as showing high (30 units) or low (<30 units) titration. Abortion rate showed a significant increase (P < 0.01) in the Treatment group (35%) compared to the Control (9%). Using logistic regression procedures, there was a significant (P < 0.0001) interaction between progesterone treatment and antibody titration. Progesterone-treated cows with a high antibody titre showed a likelihood of abortion 14.3 times higher than those not treated, while in cows with low antibody titres, exogenous progesterone had not effect. Our results do not support our starting hypothesis and suggest that progesterone supplementation in cows with high N. caninum antibody titres increases the risk of abortion possibly by affecting cell-mediated immune responses.
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http://hdl.handle.net/10459.1/58514
DOI
https://doi.org/10.1016/j.vetpar.2006.11.018
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Veterinary Parasitology, 2007, vol. 145, núm. 1-2, p. 164-167
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  • Articles publicats (Ciència Animal) [637]
  • Publicacions de projectes de recerca del Plan Nacional [2663]

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