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dc.contributor.authorMoreno Martínez, José Antonio
dc.contributor.authorDíaz-Gómez, J.
dc.contributor.authorNogareda, Carmina
dc.contributor.authorAngulo Asensio, Eduardo
dc.contributor.authorSandmann, Gerhard
dc.contributor.authorPortero Otín, Manuel
dc.contributor.authorSerrano Casasola, José Carlos Enrique
dc.contributor.authorTwyman, Richard M.
dc.contributor.authorCapell Capell, Teresa
dc.contributor.authorZhu, Changfu
dc.contributor.authorChristou, Paul
dc.date.accessioned2016-11-11T09:31:27Z
dc.date.available2016-11-11T09:31:27Z
dc.date.issued2016
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/10459.1/58475
dc.description.abstractCarotenoids are important dietary nutrients with health-promoting effects. The biofortification of staple foods with carotenoids provides an efficient delivery strategy but little is known about the fate and distribution of carotenoids supplied in this manner. The chicken provides a good model of human carotenoid metabolism so we supplemented the diets of laying hens using two biofortified maize varieties with distinct carotenoid profiles and compared the fate of the different carotenoids in terms of distribution in the feed, the hen’s livers and the eggs. We found that after a period of depletion, pro-vitamin A (PVA) carotenoids were preferentially diverted to the liver and relatively depleted in the eggs, whereas other carotenoids were transported to the eggs even when the liver remained depleted. When retinol was included in the diet, it accumulated more in the eggs than the livers, whereas PVA carotenoids showed the opposite profile. Our data suggest that a transport nexus from the intestinal lumen to the eggs introduces bottlenecks that cause chemically-distinct classes of carotenoids to be partitioned in different ways. This nexus model will allow us to optimize animal feed and human diets to ensure that the health benefits of carotenoids are delivered in the most effective manner.ca_ES
dc.description.sponsorshipThis research was supported by grants PIM2010PKB-00746 CAROMAIZE, from Ministerio de Economia y Competitividad (MINECO) Spain; RecerCaixa PC084082; and European Research Council IDEAS Proof of Concept Program Multinutrient Maize (to PC).ca_ES
dc.language.isoengca_ES
dc.publisherNatureca_ES
dc.relationMICINN/PN2008-2011/PIM2010PKB-00746
dc.relation.isformatofReproducció del document publicat a https://doi.org/10.1038/srep35346ca_ES
dc.relation.ispartofScientific Reports, 2016, vol. 6, núm. 35346ca_ES
dc.rightscc-by (c) Moreno et al., 2016ca_ES
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.titleThe distribution of carotenoids in hens fed on biofortified maize is influenced by feed composition, absorption, resource allocation and storageca_ES
dc.typearticleca_ES
dc.identifier.idgrec025055
dc.type.versionpublishedVersionca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_ES
dc.identifier.doihttps://doi.org/10.1038/srep35346


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