Suitability of analytical methods to measure solubility for the purpose of nanoregulation

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2016
Author
Tantra, Ratna
Bouwmeester, Hans
Bolea, Eduardo
Rey Castro, Carlos
David, Calin
Dogné, Jean Michel
Jarman, John
Laborda, Francisco
Laloy, Julie
Robinson, Kenneth N.
Undas, Anna K.
Van der Zande, Meike
Suggested citation
Tantra, Ratna; Bouwmeester, Hans; Bolea, Eduardo; Rey Castro, Carlos; David, Calin; Dogné, Jean Michel; ... Van der Zande, Meike. (2016) . Suitability of analytical methods to measure solubility for the purpose of nanoregulation. Nanotoxicology, 2016, vol. 10, núm. 2, p. 173-184. https://doi.org/10.3109/17435390.2015.1038661.
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Abstract
Solubility is an important physicochemical parameter in nanoregulation. If nanomaterial is completely soluble, then from a risk assessment point of view, its disposal can be treated much in the same way as “ordinary” chemicals, which will simplify testing and characterisation regimes. This review assesses potential techniques for the measurement of nanomaterial solubility and evaluates the performance against a set of analytical criteria (based on satisfying the requirements as governed by the cosmetic regulation as well as the need to quantify the concentration of free (hydrated) ions). Our findings show that no universal method exists. A complementary approach is thus recommended, to comprise an atomic spectrometry-based method in conjunction with an electrochemical (or colorimetric) method. This article shows that although some techniques are more commonly used than others, a huge research gap remains, related with the need to ensure data reliability.
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http://hdl.handle.net/10459.1/58463
DOI
https://doi.org/10.3109/17435390.2015.1038661
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Nanotoxicology, 2016, vol. 10, núm. 2, p. 173-184
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