H3PO4/metal halide induces a one-pot solvent-free esterification–halogenation of glycerol and diols
As part of our continued effort to achieve the synthesis of halohydrin esters from polyols by a sustainable method, here we report on a multicomponent inorganic acid-mediated solvent-free synthesis. The synthesis was designed to ensure few waste materials. Using this approach, the process shows a low E-factor and a high reaction mass efficiency. The new process involves the preparation of a reaction mixture containing either a fatty acid or fatty material, glycerol or diol, a halide salt and H3PO4. This mixture is heated at 100 °C for 48 h, yielding up to 88% of halohydrin ester. The process also allows recovery of pyrophosphate salts, compounds that have various applications in agriculture, and in the pharmaceutical, chemical and food industries.
Journal or Serie
RSC Advances, 2013, vol. 3, núm. 23, p. 8805-8810