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dc.contributor.authorMéndez, Jonh Jairo
dc.contributor.authorOromí Farrús, Mireia
dc.contributor.authorCervero, Maria
dc.contributor.authorBalcells Fluvià, Mercè
dc.contributor.authorTorres i Grifo, Mercè
dc.contributor.authorCanela i Garayoa, Ramon
dc.date.accessioned2016-11-03T11:26:12Z
dc.date.issued2007
dc.identifier.issn0899-0042
dc.identifier.urihttp://hdl.handle.net/10459.1/58367
dc.description.abstractPreparation of 98% ee (R)-4-chloro-2-butanol was carried out by the enzymatic hydrolysis of chlorohydrin esters, using fungal resting cells and commercial enzymes. Hydrolyzes were carried out using lipases from Candida antarctica (Novozym 435®), C. rugosa, Rhizomucor miehei (Lipozyme® IM), Burkolia cepacia, and resting cells of Rhizopus oryzae and Aspergillus flavus. The influence of the enzyme, the solvent, the temperature, and the alkyl chain length on the selectivity of hydrolyzes of isomeric mixtures of chlorohydrin esters is described. Regioselectivity was higher than 95% for some of the tested lipases. Novozym 435 allowed preparation of the (R)-4-chloro-2-butanol after 15 min of reaction at 30–40°C.ca_ES
dc.language.isoengca_ES
dc.publisherWileyca_ES
dc.relation.isformatofReproducció del document publicat a https://doi.org/10.1002/chir.20339ca_ES
dc.relation.ispartofChirality, 2007, vol. 19, núm. 1, p. 44–50ca_ES
dc.rights(c) Wiley-Liss, Inc., 2006ca_ES
dc.subjectBiocatalystca_ES
dc.subjectChlorohydrin estersca_ES
dc.subjectEnantiomerca_ES
dc.subjectOptical resolutionca_ES
dc.subjectResting cellsca_ES
dc.titleCombining regio- and enantioselectivity of lipases for the preparation of (R)-4-chloro-2-butanolca_ES
dc.typearticleca_ES
dc.identifier.idgrec010051
dc.type.versionpublishedVersionca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccessca_ES
dc.identifier.doihttps://doi.org/10.1002/chir.20339
dc.date.embargoEndDate2025-01-01


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