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dc.contributor.authorNogareda, Carmina
dc.contributor.authorLópez Gatius, Fernando
dc.contributor.authorSantolaria Blasco, Pilar
dc.contributor.authorGarcía Ispierto, Irina
dc.contributor.authorBech Sàbat, Gregori
dc.contributor.authorPabón, M.
dc.contributor.authorMezo, M.
dc.contributor.authorGonzalez-Warleta, M.
dc.contributor.authorCastro Hermida, J. A.
dc.contributor.authorYániz Pérez de Albéniz, Jesús
dc.contributor.authorAlmería, S.
dc.date.accessioned2016-09-05T09:48:31Z
dc.date.issued2007
dc.identifier.issn0304-4017
dc.identifier.urihttp://hdl.handle.net/10459.1/57770
dc.description.abstractThe dynamics of antibody production against Neospora caninum during the gestation period was examined in chronically infected dairy cows. Data were obtained from 86 pregnant parous dairy cows, 21 of which had suffered abortion. The cows belonged to two herds in which a diagnosis of N. caninum infection had been previously confirmed in aborted foetuses. Pregnancy diagnosis and blood collection were performed on post-insemination Days 40, 90, 120, 150, 180, 210, and at parturition or until the time of abortion detection. Blood plasma was tested for antibodies against N. caninum using ELISA. The non-aborting cows were divided into two groups according to whether their antibody values in the second half of gestation had increased or not, while aborting cows were classified as those showing an antibody peak before abortion or those not showing a pre-abortion peak. Differences in antibody values throughout pregnancy in each group of non-aborting and aborting cows were analysed by GLM repeated measures of analysis of variance. While 32 non-aborting cows (49%) showed a significant and consistent increase in anti-Neospora antibody values during the second half of gestation, antibody values in the remaining 33 non-aborting cows were practically constant throughout gestation. An antibody peak around abortion was observed in 11 aborting cows (52%), while antibody values in the remaining 10 aborting cows were similar before and at abortion. Seroprevalence fluctuations, defined as seronegative blood samples at some point during the gestation period, were, furthermore, observed in 2 aborting and 11 non-aborting cows. Our results indicate two clearly distinguishable types of humoral immune dynamics throughout gestation: an increased or flat production of antibodies during the second half of gestation in non-aborting animals and before abortion in aborting cows. The observation that some Neospora-infected dams can exhibit negative antibody values at any time during gestation, particularly at parturition or abortion, prompts future studies designed to explore the use of new ELISA strategies at the farm level.ca_ES
dc.description.sponsorshipThis work was supported by the Spanish CICYT, grants AGL2004-06103-C02-01/ GAN, AGL2004-06103-C02-02/GAN. García-Ispierto and Bech-Sàbat were supported by the FPU grants from the Ministerio de Educación y Ciencia, AP-2004-4279 and AP-2005-5378, respectivelyca_ES
dc.language.isoengca_ES
dc.publisherElsevierca_ES
dc.relationMIECI/PN2004-2007/AGL2004-06103-C02-01/GAN
dc.relationMIECI/PN2004-2007/AGL2004-06103-C02-02/GAN
dc.relation.isformatofReproducció del document publicat a http//dx.doi.org/10.1016/j.vetpar.2007.06.032ca_ES
dc.relation.ispartofVeterinary Parasitology, 2007, vol. 148, núm. 3-4, p. 193-199ca_ES
dc.rights(c) Elsevier B.V., 2007ca_ES
dc.subjectNeospora caninumca_ES
dc.subjectAntibody responseca_ES
dc.subjectGestationca_ES
dc.subjectDairy cowsca_ES
dc.subject.otherVaques -- Reproduccióca_ES
dc.subject.otherVaques -- Infeccionsca_ES
dc.titleDynamics of anti-Neospora caninum antibodies during gestation in chronically infected dairy cowsca_ES
dc.typearticleca_ES
dc.identifier.idgrec011665
dc.type.versionpublishedVersionca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccessca_ES
dc.identifier.doihttps://doi.org/10.1016/j.vetpar.2007.06.032
dc.date.embargoEndDate10000-01-01


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