Browsing Articles publicats (Agrotecnio Center) by Author "Fernández Castillejo, Sara"
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A functional virgin olive oil enriched with olive oil and thyme phenolic compounds improves the expression of cholesterol efflux-related genes: A randomized, crossover, controlled trial
Farràs, Marta; Arranz, Sara; Carrión Bolorino, Silvia; Subirana Cachinero, Isaac; Muñoz-Aguayo, Daniel; Blanchart, Gemma; Kool, Marjon; Solà, Rosa; Motilva Casado, Mª José; Escolà Gil, Joan Carles; Rubió Piqué, Laura; Fernández Castillejo, Sara; Pedret, Anna; Estruch Riba, Ramon; Covas Planells, María Isabel; Fitó, Montserrat; Hernáez Camba, Álvaro; Castañer, Olga (MDPI, 2019)The consumption of antioxidant-rich foods such as virgin olive oil (VOO) promotes high-density lipoprotein (HDL) anti-atherogenic capacities. Intake of functional VOOs (enriched with olive/thyme phenolic compounds (PCs)) ... -
Determinants of HDL Cholesterol Efflux Capacity after Virgin Olive Oil Ingestion: Interrelationships with Fluidity of HDL Monolayer
Fernández Castillejo, Sara; Rubió Piqué, Laura; Hernáez Camba, Álvaro; Catalán Santos, Úrsula; Pedret, Anna; Valls, Rosa M.; Mosele, Juana; Covas Planells, María Isabel; Remaley, Alan T.; Castañer, Olga; Motilva Casado, Mª José; Solà, Rosa (WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim, 2017-09-08)Scope: Cholesterol efflux capacity of HDL (CEC) is inversely associated with cardiovascular risk. HDL composition, fluidity, oxidation, and size are related with CEC. We aimed to assess which HDL parameters were CEC ... -
Hydroxytyrosol and its main plasma circulating metabolites attenuate the initial steps of atherosclerosis through inhibition of the MAPK pathway
Catalán Santos, Úrsula; López de las Hazas Mingo, María del Carmen; Piñol Felis, Carme; Rubió Piqué, Laura; Motilva Casado, Mª José; Fernández Castillejo, Sara; Solà, Rosa (Elsevier, 2018-01)The main aim of this work is to gain insight into the potential mechanisms of hydroxytyrosol (HT) and its mainplasmatic metabolites (HTmet) that improve the endothelial function. Feeding ApoE−/−mice with 10 mg/kg/day of ... -
Metabolic fate and cardiometabolic effects of phenolic compounds from red‐fleshed apple in hypercholesterolemic rats: A comparative study with common white‐fleshed apple. The AppleCOR Study
Yuste, Silvia; Ludwig, Iziar A.; Romero Fabregat, Mª Paz; Piñol Felis, Carme; Catalán Santos, Úrsula; Pedret, Anna; Valls, Rosa M.; Fernández Castillejo, Sara; Motilva Casado, Mª José; Macià i Puig, Ma Alba; Rubió Piqué, Laura (Wiley, 2021)The present study aimed to investigate the metabolic fate and the cardiometabolic effects of phenolic compounds (PC) provided by a red‐fleshed apple variety biofortified in anthocyanins (ACN). Wistar rats were feed with ... -
Phenol-enriched olive oils modify paraoxonase-related variables: A randomized, crossover, controlled trial
Fernández Castillejo, Sara; García Heredia, Ana Isabel; Solà, Rosa; Camps, Jordi; López de las Hazas Mingo, María del Carmen; Farràs, Marta; Pedret, Anna; Catalán Santos, Úrsula; Rubió Piqué, Laura; Motilva Casado, Mª José; Castañer, Olga; Covas Planells, María Isabel; Valls, Rosa M. (Wiley, 2017-05)Scope:Low paraoxonase (PON)1 activities, and high PON1 and low PON3 protein levels arecharacteristic of cardiovascular disease. Our aim was to assess short- and long-term effects ofvirgin olive oils (VOO), enriched with ... -
Phenol-Enriched Virgin Olive Oil Promotes Macrophage-Specific Reverse Cholesterol Transport In Vivo
Cedó Giné, Lídia; Fernández Castillejo, Sara; Rubió Piqué, Laura; Metso, Jari; Santos, David; Muñoz-Aguayo, Daniel; Rivas-Urbina, Andrea; Tondo i Colomer, Mireia; Méndez Lara, Karen Alejandra; Farràs, Marta; Jauhiainen, Matti; Motilva Casado, Mª José; Fitó, Montserrat; Blanco Vaca, Francisco; Solà, Rosa; Escolà Gil, Joan Carles (MDPI, 2020-08-03)The intake of olive oil (OO) enriched with phenolic compounds (PCs) promotes ex vivo HDL-mediated macrophage cholesterol efflux in humans. We aimed to determine the effects of PC-enriched virgin OO on reverse cholesterol ... -
Polyphenol rich olive oils improve lipoprotein particle atherogenic ratios and subclasses profile: a randomized, crossover, controlled trial
Fernández Castillejo, Sara; Valls, Rosa M.; Castañer, Olga; Rubió Piqué, Laura; Catalán Santos, Úrsula; Pedret, Anna; Macià i Puig, Ma Alba; Sampson, Maureen L.; Covas Planells, María Isabel; Fitó, Montserrat; Motilva Casado, Mª José; Remaley, Alan T.; Solà, Rosa (Wiley, 2016-07-08)Scope—Lipoprotein particle measures performed by nuclear magnetic resonance (NMR), and associated ratios, may be better markers for atherosclerosis risk than conventional lipid measures. The effect of two functional olive ... -
Protective effect of hydroxytyrosol and its predominant plasmatic human metabolites against endothelial dysfunction in human aortic endothelial cells
Catalán Santos, Úrsula; López de las Hazas Mingo, María del Carmen; Rubió Piqué, Laura; Fernández Castillejo, Sara; Pedret, Anna; De la Torre, Rafael; Motilva Casado, Mª José; Solà, Rosa (Wiley, 2015)Scope Hydroxytyrosol (HT) is the major phenolic compound in virgin olive oil (VOO) in free and conjugated forms that may exert health benefits against atherosclerosis. The native form of HT is undetectable in plasma due ... -
Validation of dried blood spot cards to determine apple phenolic metabolites in human blood and plasma after an acute intake of red-fleshed apple snack
Yuste, Silvia; Macià i Puig, Ma Alba; Ludwig, Iziar A.; Romero Fabregat, Mª Paz; Fernández Castillejo, Sara; Catalán Santos, Úrsula; Motilva Casado, Mª José; Rubió Piqué, Laura (Wiley, 2018)Scope: The application of dried blood spot (DBS) cards for the study in human blood of dietary polyphenol bioavailability has been poorly studied. Methods and results: An analytical method based on blood sampling with DBS ... -
Virgin olive oil enriched with its own phenolic compounds or complemented with thyme improves endothelial function: The potential role of plasmatic fat-soluble vitamins. A double blind, randomized, controlled, cross-over clinical trial
Valls, Rosa M.; Farràs, Marta; Pedret, Anna; Fernández Castillejo, Sara; Catalán Santos, Úrsula; Romeu, Marta; Giralt, Montserrat; Sáez, Guillermo T.; Fitó, Montserrat; De la Torre, Rafael; Covas Planells, María Isabel; Motilva Casado, Mª José; Solà, Rosa; Rubió Piqué, Laura (Elsevier, 2017)The aim of the present study was to assess whether different functional virgin olive oils (FVOOs) with varying phenolic compounds (PC) could protect the plasmatic fat-soluble vitamins, which in turn could improve the ...