Malignant pleural effusion: from bench to bedside
Robinson, Bruce W.
Stathopoulos, Georgios T.
MetadataShow full item record
Malignant pleural effusion (MPE) is a common but serious condition that is related with poor quality of life, morbidity and mortality. Its incidence and associated healthcare costs are rising and its management remains palliative, with median survival ranging from 3 to 12 months. During the last decade there
has been significant progress in unravelling the pathophysiology of MPE, as well as its diagnostics, imaging, and management. Nowadays, formerly bed-ridden patients are genotyped, phenotyped, and treated on an ambulatory basis. This article attempts to provide a comprehensive overview of current advances in MPE from bench to bedside. In addition, it highlights unanswered questions in current clinical practice and suggests future directions for basic and clinical research in the field.
Is part ofEuropean Respiratory Review, 2016, vol. 25, núm. 140, p. 189-198
The following license files are associated with this item:
Showing items related by title, author, creator and subject.
Porcel Pérez, José Manuel (Co-Action Publishing, 2013)The diagnosis of uremia-associated effusion is one of exclusion. A patient with an unexplained chronic pleural exudate, which cleared with dialysis, is reported. The differential diagnosis of pleural effusions in patients ...
Roman-Canal, Berta; Moiola, Cristian P.; Gatius Calderó, Sònia; Bonnin, Sarah; Ruiz Miró, Maria; González, Esperanza; Ojanguren, Amaia; Recuero, José Luis; Gil-Moreno, Antonio; Falcón-Pérez, Juan M.; Ponomarenko, Julia; Porcel Pérez, José Manuel; Matias-Guiu, Xavier; Colas, Eva (Nature Research, 2019)Lung cancer is the leading cause of cancer-related deaths among men and women in the world, accounting for the 25% of cancer mortality. Early diagnosis is an unmet clinical issue. In this work, we focused to develop a ...
Varano della Vergiliana, Julius F.; Lansley, Sally M.; Porcel Pérez, José Manuel; Bielsa Martín, Silvia; Brown, Jeremy S.; Creaney, Jenette; Temple, Suzanna E. L.; Waterer, Grant W.; Gary Lee, Y. C. (Public Library of Science, 2013)Heat shock protein 70 (HSP70) has been implicated in infection-related processes and has been found in body fluids during infection. This study aimed to determine whether pleural mesothelial cells release HSP70 in response ...