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dc.contributor.authorAlmería, S.
dc.contributor.authorNogareda, Carmina
dc.contributor.authorSantolaria Blasco, Pilar
dc.contributor.authorGarcía Ispierto, Irina
dc.contributor.authorYániz Pérez de Albéniz, Jesús
dc.contributor.authorLópez Gatius, Fernando
dc.date.accessioned2016-06-08T09:41:02Z
dc.date.issued2009
dc.identifier.issn0165-2427
dc.identifier.urihttp://hdl.handle.net/10459.1/57174
dc.description.abstractGamma interferon (IFN-g) production has been attributed a protective role against abortion in Neospora-infected dairy cows. This study investigate possible relationships between plasma levels of the N. caninum-specific immunoglobulin (Ig) isotypes IgG1 and IgG2 and IFN-g production throughout gestation in dairy cows naturally infected with the parasite. Data were obtained from 31 pregnant Neospora-seropositive animals. Blood samples were collected on gestation days 40, 90, 120, 150, 180 and 210 or until abortion. Ten pregnancies ended in abortion. One of the 11 cows producing IFN-g suffered abortion (9.1% of the cows producing IFN-g). Non-aborting cows producing IFN-g (n = 10) showed a significantly higher IgG2/IgG1 antibody ratio throughout the gestation period than cows not producing IFN-g (n = 11). A significant negative effect of IFN-g production on IgG1 antibodies was also observed, while IFN-g production did not affect IgG2 antibody levels. In contrast, higher levels of IgG2 antibodies compared to IgG1 antibodies were observed over the whole of gestation in aborting animals, both in those not producing IFN-g and in the single aborting cow that produced the cytokine. Our findings indicate that a Th1 immune response, in which IgG2 antibodies prevail, could be protective against N. caninum abortion, but only in the presence of IFN-g production. On their own, elevated IgG2 antibody titres appear to be insufficient to protect dams chronically infected with N. caninum against abortion.ca_ES
dc.description.sponsorshipThis work was supported by the Spanish CICYT, grants AGL2007-65521-C02-01/GAN and AGL2007-65521-C02-02/GAN.ca_ES
dc.language.isoengca_ES
dc.publisherElsevierca_ES
dc.relationMIECI/PN2004-2007/AGL2007-65521-C02-01/GANca_ES
dc.relationMIECI/PN2004-2007/AGL2007-65521-C02-02/GANca_ES
dc.relation.isformatofReproducció del document publicat a https://doi.org/10.1016/j.vetimm.2009.01.003ca_ES
dc.relation.ispartofVeterinary Immunology and Immunopathology, 2009, vol. 130, núm. 1-2, p. 35-42ca_ES
dc.rights(c) Elsevier B.V., 2009ca_ES
dc.subjectNeospora caninumca_ES
dc.subjectIgG1 antibodiesca_ES
dc.subjectIgG2 antibodiesca_ES
dc.subjectIFN-gammaca_ES
dc.titleSpecific anti-Neospora caninum IgG1 and IgG2 antibody responses during gestation in naturally infected cattle and their relationship with gamma interferon productionca_ES
dc.typearticleca_ES
dc.identifier.idgrec014027
dc.type.versionpublishedVersionca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccessca_ES
dc.identifier.doihttps://doi.org/10.1016/j.vetimm.2009.01.003
dc.date.embargoEndDate2025-01-01


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