Transgenic multivitamin corn through biofortification of endosperm with three vitamins representing three distinct metabolic pathways
Pérez Conesa, Darío
MetadataShow full item record
Vitamin deficiency affects up to 50% of the world’s population, disproportionately impacting on developing countries where populations endure monotonous, cereal-rich diets. Transgenic plants offer an effective way to increase the vitamin content of staple crops, but thus far it has only been possible
to enhance individual vitamins. We created elite inbred South African transgenic corn plants in which the levels of 3 vitamins were increased specifically in the endosperm through the simultaneous modification of 3 separate metabolic pathways. The transgenic kernels contained 169-fold the normal amount of -carotene, 6-fold the normal amount of ascorbate, and double the normal amount of folate. Levels of engineered vitamins remained stable at least through to the T3 homozygous generation. This achievement, which vastly exceeds any realized thus far by conventional breeding alone, opens the way for the development of nutritionally complete cereals to benefit the world’s poorest people.
Is part ofProceedings of the National Academy of Sciences, 2009, vol. 12, núm. 19, p. 7762-7767
European research projects
Showing items related by title, author, creator and subject.
Capell Capell, Teresa; Zhu, Changfu; Bassie Rene, Ludovic; Peremartí, Ariadna; Naqvi, Shaista; Ramessar, Koreen; Gómez Galera, Sonia; Christou, Paul (Institut d'Estudis Catalans. Secció de Ciències i Tecnologia, 2007)Les plantes transgèniques són una part integral de l’agricultura contemporània. Durant l’any 2006 més de noranta milions d’hectàrees de plantes transgèniques van ser cultivades en vint-i-un països. Des de la comercialització ...
Synergistic metabolism in hybrid corn indicates bottlenecks in the carotenoid pathway and leads to the accumulation of extraordinary levels of the nutritionally important carotenoid zeaxanthin Naqvi, Shaista; Zhu, Changfu; Farré Martinez, Gemma; Sandmann, Gerhard; Capell Capell, Teresa; Christou, Paul (Wiley, 2011)Lutein and zeaxanthin cannot be synthesized de novo in humans, and althoughlutein is abundant in fruit and vegetables, good dietary sources of zeaxanthin arescarce. Certain corn varieties provide adequate amounts because ...
Targeted transcriptomic and metabolic profiling reveals temporal bottlenecks in the maize carotenoid pathway that may be addressed by multigene engineering Farré Martinez, Gemma; Rivera Vélez, Sol Maiam; Alves, Rui; Vilaprinyo Terré, Ester; Sorribas Tello, Albert; Canela i Garayoa, Ramon; Naqvi, Shaista; Sandmann, Gerhard; Capell Capell, Teresa; Zhu, Changfu; Christou, Paul (Wiley, 2013)Carotenoids are a diverse group of tetraterpenoid pigments found in plants, fungi, bacteria and some animals. They play vital roles in plants and provide important health benefits to mammals, including humans. We ...