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dc.contributor.authorNaqvi, Shaista
dc.contributor.authorFarré Martinez, Gemma
dc.contributor.authorZhu, Changfu
dc.contributor.authorSandmann, Gerhard
dc.contributor.authorCapell Capell, Teresa
dc.contributor.authorChristou, Paul
dc.date.accessioned2016-06-06T10:22:39Z
dc.date.issued2011
dc.identifier.issn0962-8819
dc.identifier.urihttp://hdl.handle.net/10459.1/57159
dc.description.abstractThe quantity and composition of tocopherols (compounds with vitamin E activity) vary widely among different plant species reflecting the expression, activity and substrate specificity of enzymes in the corresponding metabolic pathway. Two Arabidopsis cDNA clones corresponding to q-hydroxyphenylpyruvate dioxygenase (HPPD) and 2-methyl-6-phytylplastoquinol methyltransferase (MPBQ MT) were constitutively expressed in corn to further characterize the pathway and increase the kernel tocopherol content. Transgenic kernels contained up to 3 times as much c-tocopherol as their wild type counterparts whereas other tocopherol isomers remained undetectable. Biofortification by metabolic engineering offers a sustainable alternative to vitamin E supplementation for the improvement of human health.ca_ES
dc.description.sponsorshipThis study was supported by the Ministerio de Ciencia e Innovación, Spain (BFU2007-61413); BIOFORCE ERC advanced grant to PC; S.N. and G.F. are recipients of Ph.D. fellowships from Ministerio de Ciencia e Innovacio´n, Spain (BES-2005-9161).ca_ES
dc.language.isoengca_ES
dc.publisherSpringer Verlagca_ES
dc.relationMIECI/PN2004-2007/BFU2007-61413ca_ES
dc.relation.isformatofReproducció del document publicat a https://doi.org/10.1007/s11248-010-9393-6ca_ES
dc.relation.ispartofTransgenic Research, 2011, vol. 20, núm. 1, p. 177-181ca_ES
dc.rights(c) Springer Science+Business Media B.V., 2010ca_ES
dc.subjectVitamin Eca_ES
dc.subjectTocopherolsca_ES
dc.subjectMetabolic engineeringca_ES
dc.subjectTransgenic maizeca_ES
dc.titleSimultaneous expression of Arabidopsis ρ-hydroxyphenylpyruvate dioxygenase and MPBQ methyltransferase in transgenic corn kernels triples the tocopherol contentca_ES
dc.typearticleca_ES
dc.identifier.idgrec015756
dc.type.versionpublishedVersionca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccessca_ES
dc.identifier.doihttps://doi.org/10.1007/s11248-010-9393-6
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/232933ca_ES
dc.date.embargoEndDate2025-01-01


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