Glial Modulation by N-acylethanolamides in Brain Injury and Neurodegeneration

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Date
2016
Authors
Herrera, María Inés
Kölliker Frers, Rodolfo
Barreto, George
Blanco Calvo, EduardoBlanco Calvo, Eduardo - ORCID ID
Capani, Francisco
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Abstract
Neuroinflammation involves the activation of glial cells and represents a key element in normal aging and pathophysiology of brain damage. N-acylethanolamides (NAEs), naturally occurring amides, are known for their pro-homeostatic effects. An increase in NAEs has been reported in vivo and in vitro in the aging brain and in brain injury. Treatment with NAEs may promote neuroprotection and exert anti-inflammatory actions via PPARα activation and/or by counteracting gliosis. This review aims to provide an overview of endogenous and exogenous properties of NAEs in neuroinflammation and to discuss their interaction with glial cells.
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Frontiers in Aging Neuroscience, 2016, vol. 8, núm. 81, p. 1-10