Telomere length is a prognostic factor for overall survival in colorectal cancer
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Date
2011
Authors
Valls i Bautista, Cristina
Piñol Felis, Carme
Reñé Espinet, Josep Maria
Buenestado Garcia, Juan
Viñas Salas, Joan
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Abstract
Aim The aim of this study was to determine whether
telomere length is an independent prognostic factor for
the prevention and survival of colorectal cancer.
Method Terminal restriction fragment (TRF) length was
determined by Southern blot in tumours and paired
normal tissue samples from 147 patients with sporadic
colorectal cancer who had undergone surgery. The TRF
length ratio (TRFLR) was determined as the ratio
between the length of the patient’s tumour and normal
tissue.The classification and regression tree technique was
used to determine optimal cut-off values (£ 1 or > 1).
Results Mean TRF length was 6.79 Kbp (1.19–13.99)
in tumour tissue and 7.81 Kbp (3.63–15.70) in normal
mucosa (P < 0.001). Mean TRFLR was 0.88. Telomere
length and telomere length ratio were not correlated with
any clinicopathological factors. In univariate analysis,
overall survival was related to N stage (lymph node + ⁄ );
P = 0.002), TNM classification (P = 0.019) and TRFLR
(£ 1 or > 1; P = 0.014). In multivariate analysis, overall
survival was significantly associated with TRFLR and N
stage. Colorectal cancer patients with TRFLR £ 1 and
negative lymph node involvement had a higher overall
survival rate.
Conclusion Telomere length ratio is an independent
prognostic factor for survival in colorectal cancer patients,
and the telomere lengths in the normal and tumour
mucosa of the same patient present with parallel
behaviour.
Citation
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Colorectal Disease, 2011, vol. 13, núm.11