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dc.contributor.authorMur, Maria
dc.contributor.authorPortella, Maria J.
dc.contributor.authorMartínez-Aran, A.
dc.contributor.authorPifarré Paredero, Josep
dc.contributor.authorVieta i Pascual, Eduard, 1963-
dc.date.accessioned2016-06-01T09:36:36Z
dc.date.issued2008
dc.identifier.issn0001-690X
dc.identifier.urihttp://hdl.handle.net/10459.1/57142
dc.description.abstractObjective: To investigate the cognitive impairment of a sample of euthymic bipolar patients treated with lithium monotherapy at baseline in a 2-year longitudinal study. Method: Fifteen DSM-IV-TR bipolar out-patients and 15 healthy-matched controls were cognitively assessed twice over a 2-year follow-up. All patients underwent lithium monotherapy on the first evaluation, and they were euthymic in both evaluations. Cognitive assessment was performed by means of a neuropsychological test battery tapping into the main cognitive domains (executive function, attention, processing speed, verbal memory and visual memory). Results: Repeated measures multivariate analysis of variance showed that the bipolar disorder group was cognitively impaired in the executive domain, attention and processing speed, and such deficits were maintained over time. Conclusion: Our results showed that executive dysfunction is the main long-term neuropsychological deficit of bipolar disorder. Also, the persistence of these deficits did not seem to be influenced by any clinical or pharmacological variables.ca_ES
dc.description.sponsorshipThis study was supported partly by grant 15231 ⁄ 01 from Fundació Marató de TV3 (Drs Mur and Pifarré). Also supported by the Spanish Ministry of Health, Instituto de Salud Carlos III, Centro de Investigacion Biomedica en Salud Mental, CIBERSAM (Drs Portella, Martínez-Arán and Vieta). Dr Portella is funded by the Spanish Ministry of Education and Science through a Juan de la Cierva postdoctoral contract. Dr Martinez-Aran is funded by the Spanish Ministry of Health, Instituto Carlos III through a ‘‘Miguel Servet’’ postdoctoral contract (CP07 ⁄ 00144).ca_ES
dc.language.isoengca_ES
dc.publisherWileyca_ES
dc.relation.isformatofReproducció del document publicat a https://doi.org/10.1111/j.1600-0447.2008.01245.xca_ES
dc.relation.ispartofActa Psychiatrica Scandinavica, 2008, vol. 118, núm. 5, p. 373-381ca_ES
dc.rights(c) Wiley, 2008ca_ES
dc.subjectBipolar disorderca_ES
dc.subjectEuthymiaca_ES
dc.subjectLithiumca_ES
dc.subjectNeuropsychological impairmentca_ES
dc.titleNeuropsychological profile in bipolar disorder: a preliminary study of monotherapy lithium-treated euthymic bipolar patients evaluated at a 2-year intervalca_ES
dc.typearticleca_ES
dc.identifier.idgrec017104
dc.type.versionpublishedVersionca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccessca_ES
dc.identifier.doihttps://doi.org/10.1111/j.1600-0447.2008.01245.x
dc.date.embargoEndDate2025-01-01


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