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dc.contributor.authorYamagishi, Satoru
dc.contributor.authorHampel, Falko
dc.contributor.authorHata, Katsuhiko
dc.contributor.authorToro, Daniel del
dc.contributor.authorSchwark, Manuela
dc.contributor.authorKvachnina, Elena
dc.contributor.authorBastmeyer, Martin
dc.contributor.authorYamashita, Toshihide
dc.contributor.authorTarabykin, Victor
dc.contributor.authorKlein, Rüdiger
dc.contributor.authorEgea Navarro, Joaquim
dc.date.accessioned2016-06-01T08:13:36Z
dc.date.issued2011
dc.identifier.issn0261-4189
dc.identifier.urihttp://hdl.handle.net/10459.1/57136
dc.description.abstractNetrin-1 induces repulsive axon guidance by binding to the mammalian Unc5 receptor family (Unc5A–Unc5D). Mouse genetic analysis of selected members of the Unc5 family, however, revealed essential functions independent of Netrin-1, suggesting the presence of other ligands. Unc5B was recently shown to bind fibronectin and leucine-rich transmembrane protein-3 (FLRT3), although the relevance of this interaction for nervous system development remained unclear. Here, we show that the related Unc5D receptor binds specifically to another FLRT protein, FLRT2. During development, FLRT2/3 ectodomains (ECDs) are shed from neurons and act as repulsive guidance molecules for axons and somata of Unc5-positive neurons. In the developing mammalian neocortex, Unc5D is expressed by neurons in the subventricular zone (SVZ), which display delayed migration to the FLRT2-expressing cortical plate (CP). Deletion of either FLRT2 or Unc5D causes a subset of SVZ-derived neurons to prematurely migrate towards the CP, whereas overexpression of Unc5D has opposite effects. Hence, the shed FLRT2 and FLRT3 ECDs represent a novel family of chemorepellents for Unc5-positive neurons and FLRT2/ Unc5D signalling modulates cortical neuron migration.ca_ES
dc.description.sponsorshipThis work was in part funded by the Max Planck Society (to RK and VT), by the Deutsche Forschungsgemeinschaft (SFB665 and Heisenberg Program to VT) and by the Generalitat de Catalunya (SGR740) and Ministerio de Ciencia e Innovación (BFU2010-18055) (to JE).ca_ES
dc.language.isoengca_ES
dc.publisherEMBO Pressca_ES
dc.relationMICINN/PN2008-2011/BFU2010-18055
dc.relation.isformatofReproducció del document publicat a https://doi.org/10.1038/ emboj.2011.189ca_ES
dc.relation.ispartofEMBO Journal, 2011, vol. 30, núm. 14ca_ES
dc.rights(c) EMBO Press, 2011ca_ES
dc.subjectCell migrationca_ES
dc.subjectCortex developmentca_ES
dc.subjectFLRTca_ES
dc.titleFLRT2 and FLRT3 act as repulsive guidance cues for Unc5-positive neuronsca_ES
dc.typearticleca_ES
dc.identifier.idgrec017849
dc.type.versionpublishedVersionca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccessca_ES
dc.identifier.doihttps://doi.org/10.1038/ emboj.2011.189
dc.date.embargoEndDate2025-01-01


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