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dc.contributor.authorAyala Jové, Ma. Victoria (Maria Victoria)
dc.contributor.authorNaudí i Farré, Alba
dc.contributor.authorSanz, Alberto
dc.contributor.authorCaro, Pilar
dc.contributor.authorPortero Otín, Manuel
dc.contributor.authorBarja, Gustavo
dc.contributor.authorPamplona Gras, Reinald
dc.date.accessioned2016-06-01T08:08:04Z
dc.date.issued2007
dc.identifier.issn1079-5006
dc.identifier.urihttp://hdl.handle.net/10459.1/57135
dc.description.abstractCaloric restriction (CR) decreases oxidative damage, which contributes to the slowing of aging rate. It is not known if such decreases are due to calories themselves or specific dietary components. In this work, the ingestion of proteins of Wistar rats was decreased by 40% below that of controls. After 7 weeks, the liver of the protein-restricted (PR) animals showed decreases in oxidative protein damage, degree of membrane unsaturation, and mitochondrial complex I content. The results and previous information suggest that the decrease in the rate of aging induced by PR can be due in part to decreases in mitochondrial reactive oxygen species production and DNA and protein oxidative modification, increases in fatty acid components more resistant to oxidative damage, and decreased expression of complex I, analogously to what occurs during CR. Recent studies suggest that those benefits of PR could be caused, in turn, by the lowered methionine intake of that dietary manipulationca_ES
dc.description.sponsorshipThis study was supported in part by IþD grants from the Spanish Ministry of Education and Science (BFU2006-14495/BFI), the Generalitat of Catalunya (2005SGR00101), ‘‘La Marato TV3’’ Foundation, ‘‘La Caixa’’ Foundation, and the Spanish Ministry of Health to R.P. and M.P.O.; and from the Spanish Ministry of Science and Technology (SAF2002- 01635) and the Ministry of Education and Science (BFU2005-02584) to G.B.ca_ES
dc.language.isoengca_ES
dc.publisherOxford University Pressca_ES
dc.relationMIECI/PN2004-2007/BFU2006-14495/BFI
dc.relationMICYT/PN2000-2003/SAF2002-01635
dc.relationMIECI/PN2004-2007/BFU2005-02584
dc.relation.isformatofReproducció del document publicat a http://biomedgerontology.oxfordjournals.org/content/62/4/352.longca_ES
dc.relation.ispartofJournals of Gerontology, Series A, 2007, vol. 62, núm. 4, p. 352-360ca_ES
dc.rights(c) The Gerontological Society of America, 2007ca_ES
dc.titleDietary protein restriction decreases oxidative protein damage, peroxidizability index, and mitochondrial complex I content in rat liverca_ES
dc.typearticleca_ES
dc.identifier.idgrec009193
dc.type.versionpublishedVersionca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccessca_ES
dc.date.embargoEndDate2025-01-01


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