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dc.contributor.authorWegmeyer, Heike
dc.contributor.authorEgea Navarro, Joaquim
dc.contributor.authorRabe, Nadine
dc.contributor.authorGezelius, Henrik
dc.contributor.authorFilosa, Alessandro
dc.contributor.authorEnjin, Anders
dc.contributor.authorVaroqueaux, Frederique
dc.contributor.authorDeininger, Katrin
dc.contributor.authorSchnütgen, Frank
dc.contributor.authorBrose, Nils
dc.contributor.authorKlein, Rüdiger
dc.contributor.authorKullander, Klas
dc.contributor.authorBetz, Andrea
dc.date.accessioned2016-05-27T09:33:49Z
dc.date.issued2007
dc.identifier.issn0896-6273
dc.identifier.urihttp://hdl.handle.net/10459.1/57111
dc.description.abstractNeuronal network formation in the developing nervous system is dependent on the accurate navigation of nerve cell axons and dendrites, which is controlled by attractive and repulsive guidance cues. Ephrins and their cognate Eph receptors mediate many repulsive axonal guidance decisions by intercellular interactions resulting in growth cone collapse and axon retraction of the Eph-presenting neuron. We show that the Rac-specific GTPase-activating protein a2-chimaerin binds activated EphA4 and mediates EphA4-triggered axonal growth cone collapse. a-Chimaerin mutant mice display a phenotype similar to that of EphA4 mutant mice, including aberrant midline axon guidance and defective spinal cord central pattern generator activity. Our results reveal an achimaerin-dependent signaling pathway downstream of EphA4, which is essential for axon guidance decisions and neuronal circuit formation in vivo.ca_ES
dc.language.isoengca_ES
dc.publisherElsevierca_ES
dc.relation.isformatofReproducció del document publicat a https://doi.org/10.1016/j.neuron.2007.07.038ca_ES
dc.relation.ispartofNeuron, 2007, vol. 55, núm. 5, p. 756-767ca_ES
dc.rights(c) Elsevier Inc., 2007ca_ES
dc.titleEphA4-Dependent Axon Guidance Is Mediated by the RacGAP a2-Chimaerinca_ES
dc.typearticleca_ES
dc.identifier.idgrec017845
dc.type.versionpublishedVersionca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccessca_ES
dc.identifier.doihttps://doi.org/10.1016/j.neuron.2007.07.038
dc.date.embargoEndDate2025-01-01


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