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dc.contributor.authorZhang, Jisheng
dc.contributor.authorBahi i Pla, Núria
dc.contributor.authorZubiaga, Ana M.
dc.contributor.authorComella i Carnicé, Joan Xavier
dc.contributor.authorLlovera i Tomàs, Marta
dc.contributor.authorSanchis, Daniel
dc.date.accessioned2016-05-27T08:30:30Z
dc.date.issued2007
dc.identifier.issn0014-5793
dc.identifier.urihttp://hdl.handle.net/10459.1/57106
dc.description.abstractThe involvement of caspases in postmitotic cell death is controversial. Here we report that adult brain and heart are devoid of many key pro-apoptotic proteins due to a progressive postnatal silencing event involving a reduction of their transcript levels. E2F has been shown to control cell cycle progression and to be transcriptional activator of apoptotic genes. However, our data demonstrate that apoptotic gene expression in heart, brain and liver, as well as cardiac and neuronal apoptotic gene silencing during development, are E2F-independent events. Therefore, the genes regulating caspase-dependent cell death are expressed in embryonic organs in an E2F-independent manner and a developmental-related silencing event represses these genes in postmitotic adult tissues.ca_ES
dc.description.sponsorshipThe work was partially supported by a Grant (SAF2005-02197) from the Ministry of Education and Science of Spain (MEC) to D.S., a Grant ‘‘Suport als Grups de Recerca’’ from the Government of Catalonia to JXC/MLL/DS and a Grant (SAF2005-07930-C02-01) to AMZ. DS and MLL are Ramón y Cajal MEC fellows; NB is recipient of a PhD fellowship from the Departament d’Universitats, Recerca i Societat de la Informació (Government of Catalonia). J.Z. is recipient of a PhD fellowship from MEC.ca_ES
dc.language.isoengca_ES
dc.publisherWileyca_ES
dc.relationMIECI/PN2004-2007/SAF2005-02197
dc.relationMIECI/PN2004-2007/SAF2005-07930-C02-01
dc.relation.isformatofReproducció del document publicat a https://doi.org/10.1016/j.febslet.2007.11.046
dc.relation.ispartofFEBS Letters, 2007, vol. 581, núm. 30, p. 5781-5786ca_ES
dc.rights(c) Federation of European Biochemical Societies, 2007ca_ES
dc.subjectHeartca_ES
dc.subjectBrainca_ES
dc.subjectDevelopmentca_ES
dc.subjectApoptosisca_ES
dc.titleDevelopmental silencing and independency from E2F of apoptotic gene expression in postmitotic tissuesca_ES
dc.typearticleca_ES
dc.identifier.idgrec011262
dc.type.versionpublishedVersionca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccessca_ES
dc.identifier.doihttps://doi.org/10.1016/j.febslet.2007.11.046
dc.date.embargoEndDate2025-01-01


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