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dc.contributor.authorLi, Aihong
dc.contributor.authorRué i Monné, Montserrat
dc.contributor.authorZhou, Jianbiao
dc.contributor.authorWang, Hongjun
dc.contributor.authorGoldwasser, Meredith A.
dc.contributor.authorNeuberg, Donna
dc.contributor.authorDalton, Virginia
dc.contributor.authorZuckerman, David
dc.contributor.authorLyons, Cheryl
dc.contributor.authorSilverman, Lewis B.
dc.contributor.authorSallan, Stephen E.
dc.contributor.authorGribben, John G.
dc.date.accessioned2016-05-20T07:42:15Z
dc.date.issued2004
dc.identifier.issn0006-4971
dc.identifier.urihttp://hdl.handle.net/10459.1/57063
dc.description.abstractSequence analysis of the immunoglobulin heavy chain genes (IgH) has demonstrated preferential usage of specific variable (V), diversity (D), and joining (J) genes at different stages of B-cell development and in B-cell malignancies, and this has provided insight into B-cell maturation and selection. Knowledge of the association between rearrangement patterns based on updated databases and clinical characteristics of pediatric acute lymphoblastic leukemia (ALL) is limited. We analyzed 381 IgH sequences identi- fied at presentation in 317 children with B-lineage ALL and assessed the VHDHJH gene utilization profiles. The DHJH-proximal VH segments and the DH2 gene family were significantly overrepresented. Only 21% of VH-JH joinings were potentially productive, a finding associated with a trend toward an increased risk of relapse. These results suggest that physical location at the VH locus is involved in preferential usage of DHJH-proximal VH segments whereas DH and JH segment usage is governed by position-independent molecular mechanisms. Molecular pathophysiology appears relevant to clinical outcome in patients who have only productive rearrangements, and specific rearrangement patterns are associated with differences in the tumor biology of childhood ALL.ca_ES
dc.language.isoengca_ES
dc.publisherAmerican Society of Hematologyca_ES
dc.relation.isformatofReproducció del document publicat a https://doi.org/10.1182/blood-2003-11-3857ca_ES
dc.relation.ispartofBlood, 2004, vol. 103, núm. 12, p. 4602-4609ca_ES
dc.rights(c) The American Society of Hematology, 2004ca_ES
dc.titleUtilization of Ig heavy chain variable, diversity, and joining gene segments in children with B-lineage acute lymphoblastic leukemia: implications for the mechanisms of VDJ recombination and for pathogenesisca_ES
dc.typearticleca_ES
dc.identifier.idgrec009161
dc.type.versionpublishedVersionca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccessca_ES
dc.identifier.doihttps://doi.org/10.1182/blood-2003-11-3857
dc.date.embargoEndDate2025-01-01


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