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dc.contributor.authorLlovera i Tomàs, Marta
dc.contributor.authorTouraine, Philippe
dc.contributor.authorKelly, Paul A.
dc.contributor.authorGoffin, Vincent
dc.date.accessioned2016-05-09T08:15:36Z
dc.date.issued2000
dc.identifier.issn0531-5565
dc.identifier.urihttp://hdl.handle.net/10459.1/56981
dc.description.abstractThe mammary gland is the major target tissue of prolactin (PRL) in mammals. Although this pituitary hormone has been long suspected to be involved in the progression of human breast cancer, the failure of clinical improvement by treatment with dopamine agonists (which lower circulating levels of PRL) rapidly reduced the interest of oncologists concerning a potential role of PRL in the development of breast cancer. Within the last few years, however, several studies reported first, that PRL is also synthesized by mammary epithelial cells, and second that it may exert a proliferative action in an autocrine/paracrine manner. In agreement with a recent epidemiological study, these observations have led to a reconsideration of the role of PRL as an active participant in breast cancer, and are an impetus to redefine the molecular targets of anti-prolactin strategies since dopamine analogs are assumed to be inefficient on extrapituitray PRL synthesis. In this review, we briefly summarize the current knowledge of PRL effects on both normal and tumor mammary cells, and we discuss the most relevant articles supporting the autocrine-paracrine action of PRL in the breast. With the aim of defining putative new molecular targets, we propose an overview of the main PRL receptor signaling cascades known to be triggered by PRL in mammary epithelial cells or, when not available, in other cell types. Finally, because proteolytic fragments of rat PRL have been shown to inhibit the angiogenic process, which may be relevant for preventing the progression of solid tumors such as breast tumors, we discuss the hypothesis that the enzymatic cleavage of human PRL could also represent a new molecular target in the search for alternative strategies in the treatment of breast cancer.ca_ES
dc.language.isoengca_ES
dc.publisherElsevierca_ES
dc.relation.isformatofReproducció del document publicat a https://doi.org/10.1016/S0531-5565(99)00078-9ca_ES
dc.relation.ispartofExperimental Gerontology, 2000, vol. 35, núm. 1, p. 41-51ca_ES
dc.rights(c) Elsevier Science Inc., 2000ca_ES
dc.subjectProlactinca_ES
dc.subjectMammary glandca_ES
dc.subjectBreast cancerca_ES
dc.subjectSignalingca_ES
dc.titleInvolvement of prolactin in breast cancer: redefining the molecular targetsca_ES
dc.typearticleca_ES
dc.identifier.idgrec008516
dc.type.versionpublishedVersionca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccessca_ES
dc.identifier.doihttps://doi.org/10.1016/S0531-5565(99)00078-9
dc.date.embargoEndDate2025-01-01


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