Disrupted neural processing of emotional faces in psychopathy
Harrison, Ben J.
Ibern Regàs, Immaculada
Deus Yela, Juan
Menchón, José M.
Cardoner, N. (Narcís)
MetadataShow full item record
Psychopaths show a reduced ability to recognize emotion facial expressions, which may disturb the interpersonal relationship development and successful social adaptation. Behavioral hypotheses point toward an association between emotion recognition deficits in psychopathy and amygdala dysfunction. Our prediction was that amygdala dysfunction would combine deficient activation with disturbances in functional connectivity with cortical regions of the face-processing network. Twenty-two psychopaths and 22 control subjects were assessed and functional magnetic resonance maps were generated to identify both brain activation and task-induced functional connectivity using psychophysiological interaction analysis during an emotional face-matching task. Results showed significant amygdala activation in control subjects only, but differences between study groups did not reach statistical significance. In contrast, psychopaths showed significantly increased activation in visual and prefrontal areas, with this latest activation being associated with psychopaths affective–interpersonal disturbances. Psychophysiological interaction analyses revealed a reciprocal reduction in functional connectivity between the left amygdala and visual and prefrontal cortices. Our results suggest that emotional stimulation may evoke a relevant cortical response in psychopaths, but a disruption in the processing of emotional faces exists involving the reciprocal functional interaction between the amygdala and neocortex, consistent with the notion of a failure to integrate emotion into cognition in psychopathic individuals.
Is part ofSocial Cognitive Affective Neuroscience, 2014, vol. 9, núm. 4, p. 505-512
European research projects
Showing items related by title, author, creator and subject.
Pujol Salud, Jesús; Batalla, Iolanda; Contreras-Rodríguez, Oren; Harrison, Ben J.; Pera Guardiola, Vanessa; Hernández-Ribas, Rosa; Real, Eva; Bosa, Laura; Soriano-Mas, Carles; Deus Yela, Juan; López-Solà, Marina; Pifarré Paredero, Josep; Menchón, José M.; Cardoner, N. (Narcís) (Oxford University Press, 2012)Neuroimaging research has demonstrated the involvement of a well-defined brain network in the mediation of moral judgment in normal population, and has suggested the inappropriate network use in criminal psychopathy. We ...
Contreras-Rodríguez, Oren; Pujol Salud, Jesús; Batalla, Iolanda; Harrison, Ben J.; Soriano-Mas, Carles; Deus Yela, Juan; López-Solà, Marina; Macià, Dídac; Pera Guardiola, Vanessa; Hernández-Ribas, Rosa; Pifarré Paredero, Josep; Menchón, José M.; Cardoner, N. (Narcís) (Elsevier, 2015)BACKGROUND: Psychopathy is characterized by a distinctive interpersonal style that combines callousunemotional traits with inflexible and antisocial behavior. Traditional emotion-based perspectives link emotional impairment ...
Modulatory effects of psychopathy on Wisconsin Card Sorting Test performance in male offenders with Antisocial Personality Disorder Pera Guardiola, Vanessa; Batalla, Iolanda; Bosque, Javier; Kosson, David; Pifarré Paredero, Josep; Hernández-Ribas, Rosa; Goldberg, Ximena; Contreras-Rodríguez, Oren; Menchón, José M.; Soriano-Mas, Carles; Cardoner, N. (Narcís) (Elsevier, 2016)Neuropsychological deficits in executive functions (EF) have been linked to antisocial behavior and considered to be cardinal to the onset and persistence of severe antisocial and aggressive behavior. However, when psychopathy ...