Protein carbonylation: proteomics, specificity and relevance to aging

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Data de publicació
2013Citació recomanada
Cabiscol Català, Elisa;
Tamarit Sumalla, Jordi;
Ros Salvador, Joaquim;
.
(2013)
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Protein carbonylation: proteomics, specificity and relevance to aging.
Mass Spectrometry Reviews, 2013, vol. 33, núm. 1.
https://doi.org/10.1002/mas.21375.
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Detection and quantification of protein carbonyls present in
biological samples has become a popular, albeit indirect,
method to determine the existence of oxidative stress. Moreover,
the rise of proteomics has allowed the identification of the
specific proteins targeted by protein carbonylation. This review
discusses these methodologies and proteomic strategies and
then focuses on the relationship between protein carbonylation
and aging and the parameters that may explain the increased
sensitivity of certain proteins to protein carbonylation.