Protein carbonylation: proteomics, specificity and relevance to aging

Cabiscol Català, Elisa; Tamarit Sumalla, Jordi; Ros Salvador, Joaquim

doi:https://doi.org/10.1002/mas.21375

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Data de publicació

2013

Autor/a

Cabiscol Català, Elisa

Tamarit Sumalla, Jordi

Ros Salvador, Joaquim

Citació recomanada

Cabiscol Català, Elisa; Tamarit Sumalla, Jordi; Ros Salvador, Joaquim; . (2013) . Protein carbonylation: proteomics, specificity and relevance to aging. Mass Spectrometry Reviews, 2013, vol. 33, núm. 1. https://doi.org/10.1002/mas.21375.

Resum

Detection and quantification of protein carbonyls present in biological samples has become a popular, albeit indirect, method to determine the existence of oxidative stress. Moreover, the rise of proteomics has allowed the identification of the specific proteins targeted by protein carbonylation. This review discusses these methodologies and proteomic strategies and then focuses on the relationship between protein carbonylation and aging and the parameters that may explain the increased sensitivity of certain proteins to protein carbonylation.

URI

http://hdl.handle.net/10459.1/56968

DOI

https://doi.org/10.1002/mas.21375

És part de

Mass Spectrometry Reviews, 2013, vol. 33, núm. 1