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dc.contributor.authorContreras-Rodríguez, Oren
dc.contributor.authorPujol Salud, Jesús
dc.contributor.authorBatalla, Iolanda
dc.contributor.authorHarrison, Ben J.
dc.contributor.authorSoriano-Mas, Carles
dc.contributor.authorDeus Yela, Juan
dc.contributor.authorLópez-Solà, Marina
dc.contributor.authorMacià, Dídac
dc.contributor.authorPera Guardiola, Vanessa
dc.contributor.authorHernández-Ribas, Rosa
dc.contributor.authorPifarré Paredero, Josep
dc.contributor.authorMenchón, José M.
dc.contributor.authorCardoner, N. (Narcís)
dc.date.accessioned2016-05-03T09:52:51Z
dc.date.issued2015
dc.identifier.issn0006-3223
dc.identifier.urihttp://hdl.handle.net/10459.1/56937
dc.description.abstractBACKGROUND: Psychopathy is characterized by a distinctive interpersonal style that combines callousunemotional traits with inflexible and antisocial behavior. Traditional emotion-based perspectives link emotional impairment mostly to alterations in amygdala-ventromedial frontal circuits. However, these models alone cannot explain why individuals with psychopathy can regularly benefit from emotional information when placed on their focus of attention and why they are more resistant to interference from nonaffective contextual cues. The present study aimed to identify abnormal or distinctive functional links between and within emotional and cognitive brain systems in the psychopathic brain to characterize further the neural bases of psychopathy. METHODS: High-resolution anatomic magnetic resonance imaging with a functional sequence acquired in the resting state was used to assess 22 subjects with psychopathy and 22 control subjects. Anatomic and functional connectivity alterations were investigated first using a whole-brain analysis. Brain regions showing overlapping anatomic and functional changes were examined further using seed-based functional connectivity mapping. RESULTS: Subjects with psychopathy showed gray matter reduction involving prefrontal cortex, paralimbic, and limbic structures. Anatomic changes overlapped with areas showing increased degree of functional connectivity at the medial-dorsal frontal cortex. Subsequent functional seed-based connectivity mapping revealed a pattern of reduced functional connectivity of prefrontal areas with limbic-paralimbic structures and enhanced connectivity within the dorsal frontal lobe in subjects with psychopathy. CONCLUSIONS: Our results suggest that a weakened link between emotional and cognitive domains in the psychopathic brain may combine with enhanced functional connections within frontal executive areas. The identified functional alterations are discussed in the context of potential contributors to the inflexible behavior displayed by individuals with psychopathy.ca_ES
dc.description.sponsorshipThis work was supported by the Fondo de Investigaciones Sanitarias de la Seguridad Social of Spain Grant Nos. PI050884 and PI050884, the Ministerio de Ciencia e Innovación of Spain Grant No. SAF2010-19434, the Departament de Justícia de la Generalitat de Catalunya, a National Health and Medical Research Council of Australia Clinical Career Development Award (I.D. 628509; BJH), a “Miguel Servet” contract from the Carlos III Health Institute (CP10/00604; CS-M), and the Beatriu de Pinós-A postdoctoral fellowship (2010_BP_A_00136) of the Government of Catalunya (ML-S). JD and ML-S are part of the Research Group SGR1450 of the Catalonia Government.ca_ES
dc.language.isoengca_ES
dc.publisherElsevierca_ES
dc.relationMICINN/PN2008-2011/SAF2010-19434
dc.relation.isformatofReproducció del document publicat a https://doi.org/10.1016/j.biopsych.2014.03.007ca_ES
dc.relation.ispartofBiological Psychiatry, 2015, vol. 78, núm. 9, p. 647-655ca_ES
dc.rights(c) Elsevier, 2015ca_ES
dc.subjectAmygdalaca_ES
dc.subjectDorsal executive networkca_ES
dc.subjectFlexible self-regulationca_ES
dc.titleFunctional Connectivity Bias in the Prefrontal Cortex of Psychopathsca_ES
dc.typearticleca_ES
dc.identifier.idgrec025997
dc.type.versionpublishedVersionca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccessca_ES
dc.identifier.doihttps://doi.org/10.1016/j.biopsych.2014.03.007
dc.date.embargoEndDate2025-01-01


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