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dc.contributor.authorGarcía Martínez, Celia
dc.contributor.authorLlovera i Tomàs, Marta
dc.contributor.authorAgell, Neus
dc.contributor.authorLópez-Soriano, Francisco J.
dc.contributor.authorArgilés, Josep M.
dc.date.accessioned2016-05-03T08:08:49Z
dc.date.issued1995
dc.identifier.issn0006-291X
dc.identifier.urihttp://hdl.handle.net/10459.1/56935
dc.description.abstractSeptic rats showed an enhanced expression in skeletal muscle of both 1.2 (500%) and 2.4 (530%) kb mRNAs for the peptide ubiquitin, which reflects the activity of the ATP-ubiquitin-dependent proteolytic system. An acute intravenous administration of 100 micrograms/kg body weight of human recombinant tumour necrosis factor-alpha (TNF) also resulted in an important increase in the levels of ubiquitin mRNAs in rat skeletal muscle, while administration of a similar amount of human recombinant interleukin-1-beta did not. The results presented here, together with previous observations demonstrating that TNF increases the conjugation of proteins with ubiquitin in rat skeletal muscle (1), suggest that the ubiquitin system for non-lysosomal protein degradation could have a very important role in the mechanism triggered by TNF which is responsible for enhanced muscle proteolysis in sepsis and other pathological states.ca_ES
dc.language.isoengca_ES
dc.publisherElsevierca_ES
dc.relation.isformatofReproducció del document publicat a https://doi.org/10.1006/bbrc.1995.2848ca_ES
dc.relation.ispartofBiochemical and Biophysical Research Communications, 1995, vol. 127, núm. 3, p. 839-844ca_ES
dc.rights(c) Academic Press, 1995ca_ES
dc.titleUbiquitin gene expression in skeletal muscle is increased during sepsis: involvement of TNF-alpha but not IL-1ca_ES
dc.typearticleca_ES
dc.identifier.idgrec008527
dc.type.versionpublishedVersionca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccessca_ES
dc.identifier.doihttps://doi.org/10.1006/bbrc.1995.2848
dc.date.embargoEndDate2025-01-01


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