Show simple item record

dc.contributor.authorGarcía Martínez, Celia
dc.contributor.authorAgell, Neus
dc.contributor.authorLlovera i Tomàs, Marta
dc.contributor.authorLópez-Soriano, Francisco J.
dc.contributor.authorArgilés, Josep M.
dc.date.accessioned2016-05-02T08:55:49Z
dc.date.issued1993
dc.identifier.issn0014-5793
dc.identifier.urihttp://hdl.handle.net/10459.1/56930
dc.description.abstractAn acute intravenous administration of 100 micrograms/kg body weight of recombinant tumour necrosis factor-alpha (TNF) resulted in a time-dependent increase in the levels of both free and conjugated ubiquitin in rat skeletal muscle. The effects of the cytokine were more pronounced in the red muscle soleus than in the white muscle EDL. In the former muscle type, TNF-treatment also resulted in a time-dependent increase in the percentage of free ubiquitin. The results suggest that the ubiquitin system for non-lysosomal protein degradation could have a very important role in the mechanism triggered by TNF which is responsible for enhanced muscle proteolysis in sepsis and other pathological states.ca_ES
dc.language.isoengca_ES
dc.publisherWileyca_ES
dc.relation.isformatofReproducció del document publicat a https://doi.org/10.1016/0014-5793(93)81341-Vca_ES
dc.relation.ispartofFebs Letter, 1993, vol. 323, núm. 3, p. 211-214ca_ES
dc.rights(c) Wiley-VCH Verlag GmbH & Co, 1993ca_ES
dc.subjectTNFca_ES
dc.subjectProtein metabolismca_ES
dc.subjectUbiquitinca_ES
dc.subjectCachexiaca_ES
dc.titleTumour necrosis factor-alpha increases the ubiquitinization of rat skeletal muscle proteins.ca_ES
dc.typearticleca_ES
dc.identifier.idgrec008540
dc.type.versionpublishedVersionca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccessca_ES
dc.identifier.doihttps://doi.org/10.1016/0014-5793(93)81341-V
dc.date.embargoEndDate2025-01-01


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record