Tumour necrosis factor-alpha increases the ubiquitinization of rat skeletal muscle proteins.

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Issue date
1993
Author
García Martínez, Celia
Agell, Neus
Llovera i Tomàs, Marta
López-Soriano, Francisco J.
Argilés, Josep M.
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Abstract
An acute intravenous administration of 100 micrograms/kg body weight of recombinant tumour necrosis factor-alpha (TNF) resulted in a time-dependent increase in the levels of both free and conjugated ubiquitin in rat skeletal muscle. The effects of the cytokine were more pronounced in the red muscle
soleus than in the white muscle EDL. In the former muscle type, TNF-treatment also resulted in a time-dependent increase in the percentage of free ubiquitin. The results suggest that the ubiquitin system for non-lysosomal protein degradation could have a very important role in the mechanism triggered by TNF which is responsible for enhanced muscle proteolysis in sepsis and other pathological states.
URI
http://hdl.handle.net/10459.1/56930
DOI
https://doi.org/10.1016/0014-5793(93)81341-V
Is part of
Febs Letter, 1993, vol. 323, núm. 3, p. 211-214
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