Impact of obstructive sleep apnea on the levels of placental growth factor (PlGF) and their value for predicting short-term adverse outcomes in patients with acute coronary syndrome
Barceló Bennasar, Antònia
Bauçà, Josep Miquel
Peña, Mónica de la
Masdeu, María José
Sánchez de la Torre, Alicia
MetadataShow full item record
Background Placental growth factor (PlGF) induces angiogenesis and promotes tissue repair, and plasma PlGF levels change markedly during acute myocardial infarction (AMI). Currently, the impact of obstructive sleep apnea (OSA) in patients with AMI is a subject of debate. Our objective was to evaluate the relationships between PlGF levels and both the severity of acute coronary syndrome (ACS) and short-term outcomes after ACS in patients with and without OSA. Methods A total of 538 consecutive patients (312 OSA patients and 226 controls) admitted for ACS were included in this study. All patients underwent polygraphy in the first 72 hours after hospital admission. The severity of disease and short-term prognoses were evaluated during the hospitalization period. Plasma PlGF levels were measured using an electrochemiluminescence immunoassay. Results Patients with OSA were significantly older and more frequently hypertensive and had higher BMIs than those without OSA. After adjusting for age, smoking status, BMI and hypertension, PlGF levels were significantly elevated in patients with OSA compared with patients without OSA (19.9 pg/mL, interquartile range: 16.6–24.5 pg/mL; 18.5 pg/mL, interquartile range: 14.7–22.7 pg/mL; p<0.001), and a higher apnea-hypopnea index (AHI) was associated with higher PlGF concentrations (p<0.003). Patients with higher levels of PlGF had also an increased odds ratio for the presence of 3 or more diseased vessels and for a Killip score>1, even after adjustment. Conclusions The results of this study show that in patients with ACS, elevated plasma levels of PlGF are associated with the presence of OSA and with adverse outcomes during short-term followup. Trial Registration ClinicalTrials.gov NCT01335087
Is part of2016, vol. 11, núm. 3, e0147686
European research projects
The following license files are associated with this item:
Showing items related by title, author, creator and subject.
Effect of obstructive sleep apnoea on severity and short-term prognosis of acute coronary syndrome Barbé Illa, Ferran; Sánchez de la Torre, Alicia; Abad, Jorge; Durán-Cantolla, Joaquín; Mediano, Olga; Amilibia, Jose; Masdeu, María José; Florés, Marina; Barceló Bennasar, Antònia; Peña, Mónica de la; Aldomá, Albina; Worner, Fernando; Valls Marsal, Joan; Castellà, Gerard; Sánchez de la Torre, Manuel (European Respiratory Society, 2015)The goal of this study was to evaluate the influence of obstructive sleep apnoea on the severity and short-term prognosis of patients admitted for acute coronary syndrome. Obstructive sleep apnoea was defined as an ...
Effect of Continuous Positive Airway Pressure on the Incidence of Hypertension and Cardiovascular Eventsin Nonsleepy Patients With Obstructive Sleep Apnea Barbé Illa, Ferran; Durán-Cantolla, Joaquín; Sánchez de la Torre, Manuel; Martínez Alonso, Montserrat; Carmona, Carmen; Barceló Bennasar, Antònia; Chiner, Eusebi; Masa, Juan F.; González, Mónica; Marín, J. M.; García Río, Francisco; Díaz de Atauri, María Josefa; Terán, Joaquin; Mayós Pérez, Mercè; Peña, Mónica de la; Monasterio, Carmen; Campo, Félix del; Montserrat i Capdevila, Josep (American Medical Association, 2013)Context Continuous positive airway pressure (CPAP) is the first-line treatment for patients with symptomatic obstructive sleep apnea (OSA). However, its indication for all patients with sleep-disordered breathing, ...
Effect of Patient Sex on the Severity of Coronary Artery Disease in Patients with Newly Diagnosis of Obstructive Sleep Apnoea Admitted by an Acute Coronary Syndrome Sánchez de la Torre, Alicia; Abad, Jorge; Durán-Cantolla, Joaquín; Mediano, Olga; Cabriada, Valentín; Masdeu, María José; Terán, Joaquin; Masa, Juan F.; Peña, Mónica de la; Aldomá, Albina; Worner, Fernando; Valls Marsal, Joan; Barbé Illa, Ferran; Sánchez de la Torre, Manuel (Public Library of Science, 2016)Background: The cardiovascular consequences of obstructive sleep apnoea (OSA) differ by sex. We hypothesized that sex influences the severity of acute coronary syndrome (ACS) in patients with OSA. OSA was defined as an ...