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dc.contributor.authorZhu, Changfu
dc.contributor.authorNaqvi, Shaista
dc.contributor.authorCapell Capell, Teresa
dc.contributor.authorChristou, Paul
dc.date.accessioned2016-04-12T13:55:49Z
dc.date.issued2009
dc.identifier.issn0003-9861
dc.identifier.urihttp://hdl.handle.net/10459.1/56831
dc.description.abstractKetocarotenoids such as astaxanthin and canthaxanthin have important applications in the nutraceutical, cosmetic, food and feed industries. Astaxanthin is derived from b-carotene by 3-hydroxylation and 4-ketolation at both ionone end groups. These reactions are catalyzed by b-carotene hydroxylase and b-carotene ketolase, respectively. The hydroxylation reaction is widespread in higher plants, but ketolation is restricted to a few bacteria, fungi, and some unicellular green algae. The recent cloning and characterization of b-carotene ketolase genes in conjunction with the development of effective co-transformation strategies permitting facile co-integration of multiple transgenes in target plants provided essential resources and tools to produce ketocarotenoids in planta by genetic engineering. In this review, we discuss ketocarotenoid biosynthesis in general, and characteristics and functional properties of b-carotene ketolases in particular. We also describe examples of ketocarotenoid engineering in plants and we conclude by discussing strategies to efficiently convert b-carotene to astaxanthin in transgenic plants.ca_ES
dc.description.sponsorshipThis work was supported by the Ministry of Education and Science (MEC), Spain (BFU2007-61413), the Ramon y Cajal program (MEC, Spain) and a grant from the National Natural Science Foundation of China (Grant No.: 30870222). SN is a recipient of a Ph.D. fellowship from MEC (BES-2005-9161).ca_ES
dc.language.isoengca_ES
dc.publisherElsevierca_ES
dc.relationMIECI/PN2004-2007/BFU2007-61413
dc.relation.isformatofReproducció del document publicat a https://doi.org/10.1016/j.abb.2008.10.029ca_ES
dc.relation.ispartofArchives of Biochemistry and Biophysics, 2009, vol. 483, p. 182-190ca_ES
dc.rights(c) Elsevier, 2009ca_ES
dc.subjectCarotenoidsca_ES
dc.subjectKetocarotenoidsca_ES
dc.subjectAstaxanthinca_ES
dc.titleMetabolic engineering of ketocarotenoid biosynthesis in higher plantsca_ES
dc.typearticleca_ES
dc.identifier.idgrec013150
dc.type.versionpublishedVersionca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccessca_ES
dc.identifier.doihttps://doi.org/10.1016/j.abb.2008.10.029
dc.date.embargoEndDate2025-01-01


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