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dc.contributor.authorRos Freixedes, Roger
dc.contributor.authorGol, Sofia
dc.contributor.authorPena i Subirà, Ramona Natacha
dc.contributor.authorTor i Naudí, Marc
dc.contributor.authorIbañez Escriche, Noelia
dc.contributor.authorDekkers, Jack C. M.
dc.contributor.authorEstany Illa, Joan
dc.date.accessioned2016-04-04T11:58:06Z
dc.date.available2016-04-04T11:58:06Z
dc.date.issued2016
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/10459.1/56796
dc.description.abstractIntramuscular fat (IMF) content and fatty acid composition affect the organoleptic quality and nutritional value of pork. A genome-wide association study was performed on 138 Duroc pigs genotyped with a 60k SNP chip to detect biologically relevant genomic variants influencing fat content and composition. Despite the limited sample size, the genome-wide association study was powerful enough to detect the association between fatty acid composition and a known haplotypic variant in SCD (SSC14) and to reveal an association of IMF and fatty acid composition in the LEPR region (SSC6). The association of LEPR was later validated with an independent set of 853 pigs using a candidate quantitative trait nucleotide. The SCD gene is responsible for the biosynthesis of oleic acid (C18:1) from stearic acid. This locus affected the stearic to oleic desaturation index (C18:1/C18:0), C18:1, and saturated (SFA) and monounsaturated (MUFA) fatty acids content. These effects were consistently detected in gluteus medius, longissimus dorsi, and subcutaneous fat. The association of LEPR with fatty acid composition was detected only in muscle and was, at least in part, a consequence of its effect on IMF content, with increased IMF resulting in more SFA, less polyunsaturated fatty acids (PUFA), and greater SFA/PUFA ratio. Marker substitution effects estimated with a subset of 65 animals were used to predict the genomic estimated breeding values of 70 animals born 7 years later. Although predictions with the whole SNP chip information were in relatively high correlation with observed SFA, MUFA, and C18:1/C18:0 (0.48–0.60), IMF content and composition were in general better predicted by using only SNPs at the SCD and LEPR loci, in which case the correlation between predicted and observed values was in the range of 0.36 to 0.54 for all traits. Results indicate that markers in the SCD and LEPR genes can be useful to select for optimum fatty acid profiles of pork. Dades primàries associades a l'article http://hdl.handle.net/10459.1/49297ca_ES
dc.description.sponsorshipThis research was funded by the Spanish Ministry of Economy and Competitiveness (MINECO; grants AGL2012-33529 and AGL2015-65846-R)ca_ES
dc.language.isoengca_ES
dc.publisherPublic Library of Scienceca_ES
dc.relationMICINN/PN2008-2011/AGL2012-33529ca_ES
dc.relationMINECO/PN2013-2016/AGL2015-65846-Rca_ES
dc.relation.isformatofReproducció del document publicat a https://doi.org/10.1371/journal.pone.0152496ca_ES
dc.relation.ispartofPLoS ONE, 2016, vol. 11, núm. 3, e0152496ca_ES
dc.relation.isreferencedbyhttp://hdl.handle.net/10459.1/49297
dc.rightscc-by, (c) Ros et al., 2016ca_ES
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subject.otherPorcs -- Àcids grassosca_ES
dc.subject.otherGenètica animalca_ES
dc.subject.otherCarn de porc -- Greix -- Anàlisica_ES
dc.titleGenome-Wide Association Study Singles Out SCD and LEPR as the Two Main Loci Influencing Intramuscular Fat Content and Fatty Acid Composition in Duroc Pigsca_ES
dc.typearticleca_ES
dc.identifier.idgrec024294
dc.type.versionpublishedVersionca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_ES
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0152496


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