Usefulness of imaging techniques and novel biomarkers in the prediction of cardiovascular risk in patients with chronic kidney disease in Spain: The NEFRONA project

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2010Author
Junyent, Mireia
Coll, Blai
Craver Hospital, Lourdes
Marco Mayayo, M. Paz
Sarró, Felipe
Suggested citation
Junyent, Mireia;
Martínez Alonso, Montserrat;
Borràs, Mercè;
Betriu i Bars, M. Àngels;
Coll, Blai;
Craver Hospital, Lourdes;
...
Fernández i Giráldez, Elvira.
(2010)
.
Usefulness of imaging techniques and novel biomarkers in the prediction of cardiovascular risk in patients with chronic kidney disease in Spain: The NEFRONA project.
Nefrologia, 2010, vol. 30, núm. 1, p. 119-126.
https://doi.org/10.3265/Nefrologia.pre2010.Jan.10216.
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Show full item recordAbstract
Background: Cardiovascular disease (CVD) is the leading
cause of morbidity and mortality in patients with chronic
kidney disease (CKD). Cardiovascular risk assessment in this
population is hampered by the failure of traditional risk
factors to fully account for the elevated CVD risk, mainly
due to the reverse epidemiology effect, and the presence
of risk factors specifically related to uraemia. Hereby, we
present the protocol of a prospective study aimed to assess
the predictive value of imaging techniques and biomarkers
for CVD in patients with CKD. Methods: From November
2009, 2661 asymptomatic adult patients with stages 3-5D
CKD will be recruited from nephrology services and dialysis
units throughout Spain. Eight-hundred and forty-three
participants without CKD (control group) will be also
recruited. During the follow-up, CVD events and mortality
will be recorded from all CKD patients. One trained
itinerant team will carry out a carotid ultrasound to assess
intima-media thickness and presence of plaques. A
composite atherosclerosis score will be constructed based
on carotid ultrasound data and ankle-brachial index.
Presence and type of calcifications will be assessed in
carotid, femoral and brachial arteries, and in cardiac
valves, by ultrasound. Finally, blood samples will be
collected from all participants to study biomarkers.
Discussion: The NEFRONA study will allow us to examine
the usefulness of imaging techniques and biomarkers to
assess atherosclerosis development and their predictive
value in a Spanish population with CKD.
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Nefrologia, 2010, vol. 30, núm. 1, p. 119-126European research projects
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