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dc.contributor.authorRodríguez Colman, Maria José
dc.contributor.authorReverter Branchat, Gemma
dc.contributor.authorSorolla Bardají, Maria Alba
dc.contributor.authorTamarit Sumalla, Jordi
dc.contributor.authorRos Salvador, Joaquim
dc.contributor.authorCabiscol Català, Elisa
dc.date.accessioned2016-03-30T07:40:05Z
dc.date.available2016-03-30T07:40:05Z
dc.date.issued2010
dc.identifier.issn0021-9258
dc.identifier.urihttp://hdl.handle.net/10459.1/56763
dc.description.abstractIn Saccharomyces cerevisiae, the forkhead transcription factor Hcm1 is involved in chromosome segregation, spindle pole dynamics, and budding. We found that Hcm1 interacts with the histone deacetylase Sir2 and shifts from cytoplasm to the nucleus in the G1/S phase or in response to oxidative stress stimuli. The nuclear localization of Hcm1 depends on the activity of Sir2 as revealed by activators and inhibitors of the sirtuins and the sir2 mutant. Hcm1-overexpressing cells display more mitochondria that can be attributed to increased amounts of Abf2, a protein involved in mitochondrial biogenesis. These cells also show higher rates of oxygen consumption and improved resistance to oxidative stress that would be explained by increased catalase and Sod2 activities and molecular chaperones such as Hsp26, Hsp30, and members of Hsp70 family. Microarray analyses also reveal increased expression of genes involved in mitochondrial energy pathways and those allowing the transition from the exponential to the stationary phase. Taken together, these results describe a new and relevant role of Hcm1 for mitochondrial functions, suggesting that this transcription factor would participate in the adaptation of cells from fermentative to respiratory metabolism.ca_ES
dc.description.sponsorshipThis work has been supported by grants BFU2007-66249 and CSD2007-00020 Consolider Ingenio 2010 from the Ministerio de Ciencia e Innovación (Spain) and SGR2009-00196 from the Generalitat de Catalunya.ca_ES
dc.language.isoengca_ES
dc.publisherAmerican Society for Biochemistry and Molecular Biologyca_ES
dc.relationMIECI/PN2004-2007/BFU2007-66249
dc.relation.isformatofReproducció del document publicat a https://doi.org/10.1074/jbc.M110.174763ca_ES
dc.relation.ispartofJournal of Biological Chemistry, 2010, Vol. 285, núm. 47, p. 37092-37101ca_ES
dc.rights(c) The American Society for Biochemistry and Molecular Biology, 2010ca_ES
dc.titleThe Forkhead Transcription Factor Hcm1 Promotes Mitochondrial Biogenesis and Stress Resistance in Yeastca_ES
dc.typearticleca_ES
dc.identifier.idgrec021101
dc.type.versionpublishedVersionca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_ES
dc.identifier.doihttps://doi.org/10.1074/jbc.M110.174763


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