Metabolomics predicts stroke recurrence after transient ischemic attack

View/ Open
Issue date
2015Author
Suárez-Luis, Idalmis
Sanahuja Montesinos, Jordi
Quilez Martínez, Alejandro
Farré, Joan
Benabdelhak Abbou, Ikram
Suggested citation
Jové Font, Mariona;
Mauri-Capdevila, Gerard;
Suárez-Luis, Idalmis;
Cambray Carner, Serafí;
Sanahuja Montesinos, Jordi;
Quilez Martínez, Alejandro;
...
Purroy Garcia, Francisco.
(2015)
.
Metabolomics predicts stroke recurrence after transient ischemic attack.
Neurology, 2015, vol. 84, núm. 1, p. 36-45.
https://doi.org/10.1212/WNL.0000000000001093.
Metadata
Show full item recordAbstract
Objective: To discover, by using metabolomics, novel candidate biomarkers for stroke recurrence
(SR) with a higher prediction power than present ones.
Methods: Metabolomic analysis was performed by liquid chromatography coupled to mass spectrometry
in plasma samples from an initial cohort of 131 TIA patients recruited ,24 hours after
the onset of symptoms. Pattern analysis and metabolomic profiling, performed by multivariate
statistics, disclosed specific SR and large-artery atherosclerosis (LAA) biomarkers. The use of
these methods in an independent cohort (162 subjects) confirmed the results obtained in the first
cohort.
Results: Metabolomics analyses could predict SR using pattern recognition methods. Low concentrations
of a specific lysophosphatidylcholine (LysoPC[16:0]) were significantly associated with
SR. Moreover, LysoPC(20:4) also arose as a potential SR biomarker, increasing the prediction
power of age, blood pressure, clinical features, duration of symptoms, and diabetes scale
(ABCD2) and LAA. Individuals who present early (,3 months) recurrence have a specific metabolomic
pattern, differing from non-SR and late SR subjects. Finally, a potential LAA biomarker,
LysoPC(22:6), was also described.
Conclusions: The use of metabolomics in SR biomarker research improves the predictive power of
conventional predictors such as ABCD2 and LAA. Moreover, pattern recognition methods allow us
to discriminate not only SR patients but also early and late SR cases.
Is part of
Neurology, 2015, vol. 84, núm. 1, p. 36-45European research projects
Collections
- Articles publicats (IRBLleida) [755]
- Articles publicats (Medicina) [329]
- Articles publicats (Medicina Experimental) [246]
- Publicacions de projectes de recerca del Plan Nacional [2179]
- Articles publicats (Grup de Recerca en Fisiopatologia Metabòlica) [57]
- Articles publicats (Ciències Mèdiques Bàsiques) [474]
The following license files are associated with this item:
Related items
Showing items related by title, author, creator and subject.
-
Metabolomics predicts neuroimaging characteristics of transient ischemic attack patients
Purroy Garcia, Francisco; Cambray Carner, Serafí; Mauri-Capdevila, Gerard; Jové Font, Mariona; Sanahuja Montesinos, Jordi; Farré, Joan; Benabdelhak Abbou, Ikram; Molina Seguin, Jessica; Colàs Campàs, Laura; Begué Gómez, Robert; Gil, M. Isabel; Pamplona Gras, Reinald; Portero Otín, Manuel (Elsevier, 2016)Background: Neuroimaging is essential for the diagnosis and prognosis of transient ischemic attack (TIA). The discovery of a plasmatic biomarker related to neuroimaging findings is of enormous interest because, despite ... -
N-terminal pro-brain natriuretic peptide level determined at different times identifies transient ischaemic attack patients with atrial fibrillation
Purroy Garcia, Francisco; Suárez-Luis, Idalmis; Mauri-Capdevila, Gerard; Cambray Carner, Serafí; Farré, Joan; Sanahuja Montesinos, Jordi; Piñol Ripoll, Gerard; Quilez Martínez, Alejandro; González Mingot, Cristina; Begué Gómez, Robert; Gil, M. Isabel; Fernández i Giráldez, Elvira; Benabdelhak Abbou, Ikram (Wiley, 2014-06-25)BACKGROUND AND PURPOSE: The etiological classification of patients with transient ischaemic attack (TIA) is a difficult endeavor and the use of serum biomarkers could improve the diagnostic accuracy. The aim of this study ... -
Clinical evolution of elderly adults with ischemic stroke
Vena Martínez, Ana Belén; Cambray Carner, Serafí; Quilez Martínez, Alejandro; Molina Seguin, Jessica; Colàs Campàs, Laura; Sanahuja Montesinos, Jordi; González Mingot, Cristina; Purroy Garcia, Francisco; Benabdelhak Abbou, Ikram; Mauri-Capdevila, Gerard; Gil-Villar, María Pilar (Wiley, 2016)