Assessing the impact of early detection biases on breast cancer survival of Catalan women

Roso-Llorach, Albert; Forné, Carles; Macià, Francesc; Galcerán, Jaume; Marcos-Gragera, Rafael; Rué i Monné, Montserrat

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Issue date

2014

Author

Roso-Llorach, Albert

Forné, Carles

Macià, Francesc

Galcerán, Jaume

Marcos-Gragera, Rafael

Rué i Monné, Montserrat

Abstract

Survival estimates for women with screen-detected breast cancer are affected by biases specific to early detection. Lead-time bias occurs due to the advance of diagnosis, and length-sampling bias because tumors detected on screening exams are more likely to have slower growth than tumors symptomatically

detected. Methods proposed in the literature and simulation were used to assess the impact of these biases. If lead-time and length-sampling biases were not taken into account, the median survival time of screen-detected breast cancer cases may be overestimated by 5 years and the 5-year cumulative survival probability by between 2.5 to 5 percent units.

URI

http://hdl.handle.net/10459.1/56642

Is part of

Sort, 2014, vol. 38, núm. 2, p. 139-160

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Except where otherwise noted, this item's license is described as cc-by-nc-nd, (c) Roso-Llorach et al., 2014