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dc.contributor.authorVargas, Víctor
dc.contributor.authorAllende, Helena
dc.contributor.authorLecube Torelló, Albert
dc.contributor.authorSalcedo, Maria Teresa
dc.contributor.authorBaena-Fustegueras, Juan A
dc.contributor.authorFort, José Manuel
dc.contributor.authorRivero, Joaquín
dc.contributor.authorFerrer, Roser
dc.contributor.authorCatalán, Roberto
dc.contributor.authorPardina, Eva
dc.contributor.authorRamón y Cajal, Santiago
dc.contributor.authorGuardia, Jaime
dc.contributor.authorPeinado-Onsurbe, Julia
dc.description.abstractAIM: To evaluate the effects of surgical weight loss (Roux-en-Y gastric bypass with a modified Fobi-Capella technique) on non alcoholic fatty liver disease in obese patients. METHODS: A group of 26 morbidly obese patients aged 45 ± 2 years and with a body mass index > 40 kg/m2 who underwent open surgical weight loss operations had paired liver biopsies, the first at surgery and the second after 16 ± 3 mo of weight loss. Biopsies were evaluated and compared in a blinded fashion. The presence of metabolic syndrome, anthropometric and biochemical variables were also assessed at baseline and at the time of the second biopsy. RESULTS: Percentage of excess weight loss was 72.1% ± 6.6%. There was a reduction in prevalence of metabolic syndrome from 57.7% (15 patients) to 7.7% (2 patients) (P < 0.001). Any significance difference was observed in aspartate aminotransferase or alanine aminotransferase between pre and postsurgery. There were improvements in steatosis (P < 0.001), lobular (P < 0.001) and portal (P < 0.05) inflammation and fibrosis (P < 0.001) at the second biopsy. There were 25 (96.1%) patients with non alcoholic steatohepatitis (NASH) in their index biopsy and only four (15.3%) of the repeat biopsies fulfilled the criteria for NASH. The persistence of fibrosis (F > 1) was present in five patients at second biopsy. Steatosis and fibrosis at surgery were predictors of significant fibrosis postsurgery. CONCLUSION: Restrictive mildly malabsorptive surgery provides significant weight loss, resolution of metabolic syndrome and associated abnormal liver histological features in most obese patients.ca_ES
dc.publisherBaishideng Publishing Groupca_ES
dc.relation.isformatofReproducció del document publicat a
dc.relation.ispartofWorld Journal of Hepatology, 2012, vol.4, núm. 12, p. 382-388ca_ES
dc.rightscc-by-nc, (c) Baishideng Publishing Group, 2012ca_ES
dc.subjectNon alcoholic fatty liver diseaseca_ES
dc.subjectBariatric surgeryca_ES
dc.subjectNon alcoholic steatohepatitisca_ES
dc.titleSurgically induced weight loss by gastric bypass improves non alcoholic fatty liver disease in morbid obese patientsca_ES

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cc-by-nc, (c) Baishideng Publishing Group, 2012
Except where otherwise noted, this item's license is described as cc-by-nc, (c) Baishideng Publishing Group, 2012