Surgically induced weight loss by gastric bypass improves non alcoholic fatty liver disease in morbid obese patients
Salcedo, Maria Teresa
Fort, José Manuel
Ramón y Cajal, Santiago
MetadataShow full item record
AIM: To evaluate the effects of surgical weight loss (Roux-en-Y gastric bypass with a modified Fobi-Capella technique) on non alcoholic fatty liver disease in obese patients. METHODS: A group of 26 morbidly obese patients aged 45 ± 2 years and with a body mass index > 40 kg/m2 who underwent open surgical weight loss operations had paired liver biopsies, the first at surgery and the second after 16 ± 3 mo of weight loss. Biopsies were evaluated and compared in a blinded fashion. The presence of metabolic syndrome, anthropometric and biochemical variables were also assessed at baseline and at the time of the second biopsy. RESULTS: Percentage of excess weight loss was 72.1% ± 6.6%. There was a reduction in prevalence of metabolic syndrome from 57.7% (15 patients) to 7.7% (2 patients) (P < 0.001). Any significance difference was observed in aspartate aminotransferase or alanine aminotransferase between pre and postsurgery. There were improvements in steatosis (P < 0.001), lobular (P < 0.001) and portal (P < 0.05) inflammation and fibrosis (P < 0.001) at the second biopsy. There were 25 (96.1%) patients with non alcoholic steatohepatitis (NASH) in their index biopsy and only four (15.3%) of the repeat biopsies fulfilled the criteria for NASH. The persistence of fibrosis (F > 1) was present in five patients at second biopsy. Steatosis and fibrosis at surgery were predictors of significant fibrosis postsurgery. CONCLUSION: Restrictive mildly malabsorptive surgery provides significant weight loss, resolution of metabolic syndrome and associated abnormal liver histological features in most obese patients.
Is part ofWorld Journal of Hepatology, 2012, vol.4, núm. 12, p. 382-388
European research projects
The following license files are associated with this item:
Except where otherwise noted, this item's license is described as cc-by-nc, (c) Baishideng Publishing Group, 2012
Showing items related by title, author, creator and subject.
Hepatic and Visceral Adipose Tissue 11bHSD1 Expressions are Markers of Body Weight Loss After Bariatric Surgery Pardina, Eva; Baena-Fustegueras, Juan A; Fort, José Manuel; Ferrer, Roser; Rossell, Joana; Esteve, Montserrat; Peinado Onsurbe, Julia; Grasa, Mar (Wiley online library, 2015)Cortisolemia and 11βHSD1 in liver and adipose tissue are altered in obesity. However, their participation in the development of obesity remains unclear. This study analyzed these parameters in the transition from morbid ...
Diet change afects intestinal microbiota restoration and improves vertical sleeve gastrectomy outcome in diet-induced obese rats Rossell, Joana; Brindefalk, Björn; Baena-Fustegueras, Juan A; Peinado-Onsurbe, Julia; Udekwu, Klas I. (Springer, 2020)Purpose Obesity, a worldwide health problem, is linked to an abnormal gut microbiota and is currently most efectively treated by bariatric surgery. Our aim was to characterize the microbiota of high-fat fed Sprague–Dawley ...
Iodine deficiency is higher in morbid obesity in comparison with late after bariatric surgery and non-obese women Lecube Torelló, Albert; Zafon, Carles; Gromaz, Adoración; Fort, José Manuel; Caubet, Enric; Baena-Fustegueras, Juan A; Tortosa, Frederic (Springer US, 2015)Background Iodine deficiency and obesity are worldwideoccurring health problems. Our purpose was to investigate the relationship between morbid obesity and iodine status, including subjects who lost weight after bariatric ...