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dc.contributor.authorLecube Torelló, Albert
dc.contributor.authorSampol, Gabriel
dc.contributor.authorHernández, Cristina
dc.contributor.authorRomero, Odile
dc.contributor.authorCiudin, Andreea
dc.contributor.authorSimó, Rafael
dc.date.accessioned2016-02-12T10:30:16Z
dc.date.available2016-02-12T10:30:16Z
dc.date.issued2015
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/10459.1/55708
dc.description.abstractBackground: Although sleep apnea-hypopnea syndrome (SAHS) is highly prevalent in patients with type 2 diabetes (T2D), it is unknown whether or not subjects with and without T2D share the same sleep breathing pattern. Methodology/Principal findings: A cross-sectional study in patients with SAHS according to the presence (n = 132) or not (n = 264) of T2D. Both groups were matched by age, gender, BMI, and waist and neck circumferences. A subgroup of 125 subjects was also matched by AHI. The exclusion criteria included chronic respiratory disease, alcohol abuse, use of sedatives, and heart failure. A higher apnea hypopnea index (AHI) was observed in T2D patients [32.2 (10.2–114.0) vs. 25.6 (10.2–123.4) events/hours; p = 0.002). When sleep events were evaluated separately, patients with T2D showed a significant increase in apnea events [8.4 (0.1–87.7) vs. 6.3 (0.0–105.6) e/h; p = 0.044), as well as a two-fold increase in the percentage of time spent with oxygen saturation <90% [15.7 (0.0–97.0) vs. 7.9 (0.0–95.6) %; <0.001)], higher rates of oxygen desaturation events, and also higher daily sleepiness [7.0 (0.0–21.0) vs. 5.0 (0.0–21.0); p = 0.006)] than subjects without T2D. Significant positive correlations between fasting plasma glucose and AHI, the apnea events, and CT90 were observed. Finally, multiple linear regression analyses showed that T2D was independently associated with AHI (R2 = 0.217), the apnea index (R2 = 0.194), CT90 (R2 = 0.222), and desaturation events. Conclusions/significance: T2D patients present a different pattern of sleep breathing than subject without diabetes. The most important differences are the severity of hypoxemia and the number of apneas whereas the incidence of hypopnea episodes is similar.ca_ES
dc.description.sponsorshipThis study was supported by grants from the Instituto de Salud Carlos III (Fondo de Investigación Sanitaria, PI 12/00803), and the Sociedad Española Endocrinología y Nutrición.ca_ES
dc.language.isoengca_ES
dc.publisherPublic Library of Scienceca_ES
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1371/journal.pone.0119073
dc.relation.ispartofPlos One, 2015, vol.10, núm. 3, e0119073ca_ES
dc.rightscc-by, (c) Lecube et al., 2015ca_ES
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.titleCharacterization of sleep breathing pattern in patients with type 2 diabetes: sweet sleep studyca_ES
dc.typearticleca_ES
dc.identifier.idgrec023978
dc.type.versionpublishedVersionca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_ES
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0119073


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