Characteristics of hospitalized cases of Pertussis in Catalonia and Navarra, two regions in the north of Spain

Crespo, Inma; Toledo, Diana; Soldevila, Núria; Jordán, Iolanda; Solano, Rubén; Castilla, Jesús; Caylà, Joan A.; Godoy i García, Pere; Muñoz Almagro, Carmen; Domínguez García, Àngela

doi:https://doi.org/10.1371/journal.pone.0139993.t002

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Issue date

2015

Author

Crespo, Inma

Toledo, Diana

Soldevila, Núria

Jordán, Iolanda

Solano, Rubén

Castilla, Jesús

Caylà, Joan A.

Godoy i García, Pere

Muñoz Almagro, Carmen

Domínguez García, Àngela

Other authors

Working Group on the Transmission of Pertussis in Households

Abstract

Pertussis causes a large number of cases and hospitalizations in Catalonia and Navarra. We made a study of household cases of pertussis during 2012 and 2013 in order to identify risk factors for hospitalization in pertussis cases. Each primary case reported triggered the study of their contacts.

Close contacts at home and people who were in contact for >2 hours during the transmission period of cases were included. The adjusted OR and 95% confidence intervals (CI) was calculated using logistic regression. A total of 1124 pertussis cases were detected, of which 14.9% were hospitalized. Inspiratory whoop (aOR: 1.64; CI: 1.02–2.65), apnoea (aOR: 2.47; CI: 1.51–4.03) and cyanosis (aOR: 15.51; CI: 1.87–128.09) were more common in hospitalized than in outpatient cases. Hospitalization occurred in 8.7% of correctly-vaccinated cases, 41.1% of non-vaccinated cases and 9.4% of partially-vaccinated cases. In conclusion, inspiratory whoop, apnoea and cyanosis were associated factors to hospitalization while vaccination reduced hospitalizations due to pertussis.